Akerstrom Magnus, Barregard Lars, Lundh Thomas, Sallsten Gerd
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.
Toxicol Appl Pharmacol. 2017 Apr 1;320:17-25. doi: 10.1016/j.taap.2017.02.007. Epub 2017 Feb 9.
Individuals without occupational exposure are exposed to mercury (Hg) from diet and dental amalgam. The kidney is a critical organ, but there is limited information regarding the relationship between Hg in kidney (K-Hg), urine (U-Hg), blood (B-Hg), and plasma (P-Hg).
The aim was to determine the relationship between K-Hg, U-Hg, B-Hg, and P-Hg among environmentally exposed individuals, estimate the biological half-time of K-Hg, and provide information useful for biomonitoring of Hg.
Kidney cortex biopsies and urine and blood samples were collected from 109 living kidney donors. Total Hg concentrations were determined and the relationships between K-Hg, U-Hg, P-Hg, and B-Hg were investigated in regression models. The half-time of K-Hg was estimated from the elimination constant.
There were strong associations between K-Hg and all measures of U-Hg and P-Hg (r=0.65-0.84, p<0.001), while the association with B-Hg was weaker (r=0.29, p=0.002). Mean ratios between K-Hg (in μg/g) and U-Hg/24h (in μg) and B-Hg (in μg/L) were 0.22 and 0.19 respectively. Estimates of the biological half-time varied between 30 and 92days, with significantly slower elimination in women. Adjusting overnight urine samples for dilution using urinary creatinine resulted in less bias in relation to K-Hg or U-Hg/24h, compared with other adjustment techniques.
The relationship between K-Hg and U-Hg is approximately linear. K-Hg can be estimated using U-Hg and gender. Women have longer half-time of Hg in kidney compared to men. Adjusting overnight urine samples for creatinine concentration resulted in less bias.
未接触职业汞暴露的个体可通过饮食和牙科汞合金接触汞（Hg）。肾脏是关键器官，但关于肾脏汞（K-Hg）、尿液汞（U-Hg）、血液汞（B-Hg）和血浆汞（P-Hg）之间关系的信息有限。
确定环境暴露个体中K-Hg、U-Hg、B-Hg和P-Hg之间的关系，估计K-Hg的生物半衰期，并提供对汞生物监测有用的信息。
从109名活体肾供者中采集肾皮质活检组织以及尿液和血液样本。测定总汞浓度，并在回归模型中研究K-Hg、U-Hg、P-Hg和B-Hg之间的关系。根据消除常数估计K-Hg的半衰期。
K-Hg与U-Hg和P-Hg的所有测量值之间均存在强关联（r=0.65-0.84，p<0.001），而与B-Hg的关联较弱（r=0.29，p=0.002）。K-Hg（μg/g）与U-Hg/24小时（μg）和B-Hg（μg/L）的平均比值分别为0.22和0.19。生物半衰期估计值在30至92天之间，女性的消除明显较慢。与其他调整技术相比，使用尿肌酐对过夜尿液样本进行稀释调整可减少与K-Hg或U-Hg/24小时相关的偏差。
K-Hg与U-Hg之间的关系近似线性。可使用U-Hg和性别估计K-Hg。女性肾脏中汞的半衰期比男性长。根据肌酐浓度调整过夜尿液样本可减少偏差。
