干细胞标志物 CD133 的表达与结直肠癌变中的肿瘤发展有关。
Expression of the stem cell marker CD133 is related to tumor development in colorectal carcinogenesis.
机构信息
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
出版信息
Asian J Surg. 2018 May;41(3):274-278. doi: 10.1016/j.asjsur.2016.12.002. Epub 2017 Feb 10.
BACKGROUND/OBJECTIVE: CD133 is currently considered the most robust surface marker for colorectal cancer stem cells. Two meta-analysis reports have suggested that CD133 expression is significantly associated with shorter survival, and CD133 may play an important role in the progression of colorectal cancer. However, the role of CD133 in colorectal adenoma has not been fully elucidated.
METHODS
We used immunohistochemistry to evaluate CD133 expression in 200 endoscopically resected colorectal polyps from 200 patients and 20 normal mucosae between January 1993 and December 1996.
RESULTS
CD133 staining was positive in 17.9% of the colorectal adenomas. Moreover, CD133 expression was associated with differentiation status (p = 0.003) and tumor size (p = 0.03).
CONCLUSION
CD133 might play an important role in tumor development.
背景/目的：CD133 目前被认为是结直肠肿瘤干细胞最具活力的表面标志物。两项荟萃分析报告表明，CD133 的表达与较短的生存期显著相关，CD133 可能在结直肠肿瘤的进展中发挥重要作用。然而，CD133 在结直肠腺瘤中的作用尚未完全阐明。
方法
我们使用免疫组织化学方法检测了 1993 年 1 月至 1996 年 12 月期间 200 例经内镜切除的结直肠息肉和 20 例正常黏膜中 200 例患者的 CD133 表达。
结果
结直肠腺瘤中 CD133 染色阳性率为 17.9%。此外，CD133 的表达与分化状态（p=0.003）和肿瘤大小（p=0.03）相关。
结论
CD133 可能在肿瘤发生发展中发挥重要作用。
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