Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Exp Dermatol. 2017 Aug;26(8):683-684. doi: 10.1111/exd.13320. Epub 2017 May 3.
A substantial part of ongoing research in experimental dermatology focuses on skin T cells-for that reason, we find important to highlight the pioneering work of Jan D. Bos et al. from 1987 (The skin immune system (SIS): Distribution and immunophenotype of lymphocyte subpopulations in normal skin) https://www.ncbi.nlm.nih.gov/pubmed/3494791. This key article sets the record straight, once and for all, about the presence of lymphocytes in healthy skin, characterized the immunophenotypes of subpopulations, quantified these cells and studied their location. It was perhaps the critical discoveries made by Bos et al. that fuelled the scientific community's interest in skin lymphocytes, contributing to a new generation of cutaneous immunology research. We briefly describe additional scientific breakthroughs made since 1987. Nonetheless, the study of cutaneous lymphocytes remains essential to understand the relationship of these cells to human diseases and to develop therapies that can be leveraged to selectively mobilize, enhance or deplete these cells.
实验皮肤病学的研究重点主要集中在皮肤 T 细胞上，因此，我们发现强调 Jan D. Bos 等人 1987 年的开创性工作非常重要。该文题为《皮肤免疫系统 (SIS)：正常皮肤中淋巴细胞亚群的分布和免疫表型》，文章发表于《美国国家科学院院刊》（PNAS）。https://www.ncbi.nlm.nih.gov/pubmed/3494791. 这篇关键文章彻底澄清了健康皮肤中存在淋巴细胞的问题，描述了亚群的免疫表型，对这些细胞进行了量化，并研究了它们的位置。也许正是 Bos 等人的这些关键发现激发了科学界对皮肤淋巴细胞的兴趣，推动了新一代的皮肤免疫学研究。我们简要描述了自 1987 年以来的其他科学突破。尽管如此，研究皮肤淋巴细胞对于理解这些细胞与人类疾病的关系以及开发可以选择性动员、增强或耗尽这些细胞的治疗方法仍然至关重要。
