Wang Amy, Wohrley Julie, Rosebush Julia
Pediatr Ann. 2017 Feb 1;46(2):e42-e46. doi: 10.3928/19382359-20170112-01.
Neonatal herpes simplex virus (HSV) disease is a serious, life-threatening condition that should be considered in neonates with fever, vesicular rash, culture negative sepsis, and/or seizure activity. Because signs and symptoms of neonatal HSV may closely resemble those of bacterial sepsis, a thorough history and appropriate testing are imperative to accurately confirm the diagnosis. Failure to treat vesicular lesions from HSV in the neonate leads to an approximate 75% chance of progression to disseminated disease and/or meningoencephalitis. Therefore, prompt recognition of symptoms and institution of treatment pending results of the investigation are imperative to minimize the high rates of morbidity and mortality associated with this diagnosis. [Pediatr Ann. 2017;46(2):e42-e46.].
新生儿单纯疱疹病毒（HSV）病是一种严重的、危及生命的疾病，对于出现发热、水疱性皮疹、血培养阴性败血症和/或癫痫活动的新生儿应考虑此病。由于新生儿HSV的体征和症状可能与细菌性败血症极为相似，因此完整的病史和适当的检查对于准确确诊至关重要。若不治疗新生儿的HSV水疱性皮损，发展为播散性疾病和/或脑膜脑炎的几率约为75%。因此，迅速识别症状并在检查结果出来之前开始治疗，对于将与此诊断相关的高发病率和高死亡率降至最低至关重要。[《儿科年鉴》。2017年；46(2):e42 - e46。]
