Ohlsson B L, Fall M, Frankenberg-Sommar S
Department of Applied Electronics, Chalmers University of Technology, Göteberg, Sweden.
Br J Urol. 1989 Oct;64(4):374-80. doi: 10.1111/j.1464-410x.1989.tb06046.x.
Maximal electrical stimulation (MES) administered from a laboratory device designed to deliver stimulation pulses of relatively high voltages and currents was performed in 29 patients. All had suffered from bladder overactivity for several years, either idiopathic detrusor instability or an uninhibited overactive bladder, and all had failed to respond to conservative treatment. MES was performed in female patients by means of intravaginal and intra-anal electrode carriers and in males by anal electrodes only. In some cases additional stimulation was administered by means of a single needle bipolar electrode inserted directly into the pudendal nerve. Maximal amplitude was attained after gradual increases in amplitude and the patient's adaptation to this. Stimulation was administered by the therapist but the amplitudes were determined by the patient and limited by his/her pain threshold. Alternating rectangular constant voltage pulses at a repetition rate of 10 Hz were used. Treatment consisted of 4 sessions of stimulation with intervals of 1 week between each application. All patients showed a significant increase in functional bladder capacity and 11 reported a 30% decrease in the frequency of micturition. Two patients were unaffected by stimulation with external electrodes but responded well to direct pudendal nerve stimulation. MES seems to be an effective first-line treatment for the uninhibited overactive bladder.
对29名患者进行了最大电刺激（MES），刺激由一台设计用于传递相对高电压和电流刺激脉冲的实验室设备进行。所有患者均患有膀胱过度活动症数年，病因要么是特发性逼尿肌不稳定，要么是无抑制性膀胱过度活动，且均对保守治疗无反应。女性患者通过阴道内和肛门内电极载体进行MES，男性患者仅通过肛门电极进行。在某些情况下，通过直接插入阴部神经的单针双极电极进行额外刺激。在振幅逐渐增加以及患者适应之后达到最大振幅。刺激由治疗师实施，但振幅由患者确定，并受其疼痛阈值限制。使用重复频率为10Hz的交替矩形恒定电压脉冲。治疗包括4次刺激疗程，每次治疗间隔1周。所有患者的功能性膀胱容量均显著增加，11名患者报告排尿频率降低了30%。两名患者对外用电极刺激无反应，但对阴部神经直接刺激反应良好。MES似乎是治疗无抑制性膀胱过度活动的一种有效的一线治疗方法。
