Cole J O, Pope H G, LaBrie R, Ionescu-Pioggia M
Clin Pharmacol Ther. 1978 Aug;24(2):243-52. doi: 10.1002/cpt1978242243.
In order to assess the subjective effects of nefopam, a new non-opiate analgesic, a study was designed using highly educated, young, middle-to-upper class subjects in a naturalistic setting. Results suggest that the design is capable of differentiating variations in subjective drug effects. On a number of measures, 10 mg of d-amphetamine, a modest dosage, could be distinguished from placebo, showing changes in the direction expected for stimulant drugs. Nefopam (90 mg), on the other hand, showed few differences from placebo or caffeine (300 mg). Nefopam appeared mildly dysphoric, rather than stimulant, in subjective effects.
为了评估新型非阿片类镇痛药奈福泮的主观效应，研究采用受过高等教育、年轻的中上层阶级受试者，在自然环境中进行。结果表明，该设计能够区分主观药物效应的差异。在多项指标上，10毫克右旋苯丙胺（一种适度剂量）可与安慰剂区分开来，呈现出兴奋剂药物预期方向的变化。另一方面，奈福泮（90毫克）与安慰剂或咖啡因（300毫克）相比，差异不大。奈福泮在主观效应上表现为轻度烦躁不安，而非兴奋。
