Department of Mechanical and Aerospace Engineering, The George Washington University , Washington, DC 20052, United States.
Department of Dental Materials, School of Dentistry, Kyung Hee University , Seoul 02447, Republic of Korea.
ACS Nano. 2017 Mar 28;11(3):2961-2971. doi: 10.1021/acsnano.6b08390. Epub 2017 Feb 17.
Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device applications for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications.
基于聚酰亚胺（PI）的电极已广泛应用于植入式设备中作为柔性生物传感器，用于记录生物信号。然而，由于神经组织压缩、机械失配以及神经组织与电极之间的流体交换不足，基于 PI 的神经电极获得的长期神经信号质量往往会下降。在这里，我们通过开发基于聚酰亚胺纳米纤维（NF）的神经电极解决了这些问题，该电极可通过静电纺丝和喷墨打印进行制造。我们展示了一种基于 NF 的神经电极，由于其高通透性、灵活性和生物相容性，因此可以简单制造并轻松应用。此外，该电极可以长时间记录稳定的神经信号，从而减少机械失配、神经压缩和接触面积。具有高度灵活和体液可渗透性能的 NF 基电极可能为未来的神经接口应用提供支持。
