Lowry R B, Thunem N Y, Anderson-Redick S
Department of Paediatrics, University of Calgary, Alta.
CMAJ. 1989 Dec 1;141(11):1155-9.
The Alberta Congenital Anomalies Surveillance System was started in 1966 in response to the thalidomide tragedy earlier in the decade. It was one of four provincial surveillance systems on which the federal government relied for baseline statistics of congenital anomalies. The government now collects data from six provinces and one territory. The Alberta Congenital Anomaly Surveillance System originally depended on three types of notification to the Division of Vital Statistics, Department of Health, Government of Alberta: birth notice and certificates of death and stillbirth; increased sources of ascertainment have greatly improved data quality. We present the data for 1980-86 and compare the prevalence rates of selected anomalies with the rates from three other surveillance systems. Surveillance systems do not guarantee that a new teratogen will be detected, but they are extremely valuable for testing hypotheses regarding causation. At the very least they provide baseline data with which to compare any deviation or trend. For many, if not most, congenital anomalies total prevention is not possible; however, surveillance systems can be used to measure progress in prevention.
艾伯塔省先天性异常监测系统于1966年启动,以应对该十年早些时候的沙利度胺悲剧。它是联邦政府赖以获取先天性异常基线统计数据的四个省级监测系统之一。政府现在从六个省和一个地区收集数据。艾伯塔省先天性异常监测系统最初依赖于向艾伯塔省政府卫生部生命统计司提供的三种通知:出生通知、死亡证明和死产证明;增加的确定来源极大地提高了数据质量。我们展示了1980 - 1986年的数据,并将选定异常的患病率与其他三个监测系统的患病率进行了比较。监测系统不能保证检测到新的致畸物,但它们对于检验有关因果关系的假设非常有价值。至少它们提供了用于比较任何偏差或趋势的基线数据。对于许多(如果不是大多数)先天性异常来说,完全预防是不可能的;然而,监测系统可用于衡量预防工作的进展。