描述和量化青光眼结构和功能变化之间的时间关系。
Characterizing and quantifying the temporal relationship between structural and functional change in glaucoma.
机构信息
Eugene and Marilyn Glick Eye Institute, Indiana University, Indianapolis, IN, United States of America.
Department of Radiation Oncology, University of California, Los Angeles, CA, United States of America.
出版信息
PLoS One. 2021 Apr 1;16(4):e0249212. doi: 10.1371/journal.pone.0249212. eCollection 2021.
PURPOSE
To characterize and quantify the temporal relationship between structural and functional change in glaucoma.
METHODS
120 eyes of 120 patients with ocular hypertension or primary open-angle glaucoma were selected from the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study. Patients had 11 visits, separated by at least 3 months over 5 to 10 years. Each visit had rim area (RA) and mean sensitivity (MS) measurements taken within a 30-day period. The structure-function (SF) relationship was summarized using conventional and modified cross-correlation functions (CCFs), which identified the strongest absolute and positive correlation, respectively. Patients were categorized in one of the following three groups: RA and MS evolved simultaneously (lag = 0), RA preceded MS (lag<0), and MS preceded RA (lag>0). Lagging regression analysis was used to examine the variations of the SF relationship within groups.
RESULTS
The number of participants, mean visit lag, and mean correlation (standard deviation) were, for the conventional and modified CCFs, respectively: lag = 0 [16, 0, 0.53 (0.10) and 16, 0, 0.46 (0.11)]; lag<0 [50, -2.94, 0.51 (0.11) and 55, -3.45, 0.44 (0.12)], and lag>0 [54, 3.35, 0.53 (0.13) and 49, 3.78, 0.45 (0.12)]. A significant difference of the visit lag relation within groups was identified using lagging regression analysis (p<0.0001).
CONCLUSIONS
The strongest relationship between structure and function was obtained at different visit lags in different patients. This finding also suggests that the SF relationship should be addressed at the subject level when using both measurements jointly to model glaucoma progression.
目的
描述和量化青光眼结构和功能变化之间的时间关系。
方法
从诊断性青光眼创新研究或非裔美国人青光眼评估研究中选择了 120 名患有眼压升高或原发性开角型青光眼的患者的 120 只眼。患者有 11 次就诊，至少间隔 3 个月，时间跨度为 5 至 10 年。每次就诊均在 30 天内进行边缘区域（RA）和平均敏感度（MS）测量。使用传统和改进的互相关函数（CCF）来总结结构-功能（SF）关系，分别确定最强的绝对和正相关。将患者分为以下三组之一：RA 和 MS 同时演变（滞后=0），RA 先于 MS（滞后<0），MS 先于 RA（滞后>0）。滞后回归分析用于检查组内 SF 关系的变化。
结果
对于传统和改进的 CCF，参与者数量、平均就诊滞后和平均相关性（标准差）分别为：滞后=0 [16，0，0.53（0.10）和 16，0，0.46（0.11）]；滞后<0 [50，-2.94，0.51（0.11）和 55，-3.45，0.44（0.12）]，滞后>0 [54，3.35，0.53（0.13）和 49，3.78，0.45（0.12）]。滞后回归分析确定了组内就诊滞后关系的显著差异（p<0.0001）。
结论
在不同的患者中，在不同的就诊滞后时间获得了结构和功能之间最强的关系。这一发现还表明，当联合使用这两种测量方法来模拟青光眼进展时，SF 关系应该在个体水平上进行处理。
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