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当前外科手术时代成年患者冠状动脉旁路移植术和瓣膜手术后永久性起搏器植入的预测因素

Predictors of Permanent Pacemaker Implantation After Coronary Artery Bypass Grafting and Valve Surgery in Adult Patients in Current Surgical Era.

作者信息

Al-Ghamdi Bandar, Mallawi Yaseen, Shafquat Azam, Ledesma Alexandra, AlRuwaili Nadiah, Shoukri Mohamed, Khan Shahid, Al Sanei Aly

机构信息

Heart Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Heart Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

出版信息

Cardiol Res. 2016 Aug;7(4):123-129. doi: 10.14740/cr480w. Epub 2016 Sep 5.

Abstract

BACKGROUND

Permanent pacemaker (PPM) implantation after cardiac surgery is required in 0.4-6% of patients depending on cardiac surgery type. PPM implantation in the early postoperative period may reduce morbidity and postoperative hospital stay. We performed a retrospective review of electronic medical records of adult patients with coronary artery bypass grafting (CABG), valve surgery, or both, over a 3-year period. Our aim was to identify predictors of PPM requirements and PPM dependency on follow-up in the current surgical era.

METHODS

After exclusion of patients with congenital heart disease, patients who already had a PPM or implantable cardioverter defibrillator (ICD), and patients with an indication for PPM or ICD before surgery, we identified 1,234 adult patients who underwent cardiac surgery between January 2007 and December 2009. A retrospective review of electronic medical records and pacemaker clinic data was performed.

RESULTS

Patients' mean age was 46.65 ± 16 years, and 59% were males. CABG was performed in 575 (46.6%) cases, aortic valve replacement in 263 (21.3%), mitral valve replacement in 333 (27%), and tricuspid valve replacement in 76 patients (6.2%). Twenty patients (1.6%) required implantation of a PPM postoperatively. Indications for PPM implantation included complete atrioventricular (AV) block in 13 (65%), sick sinus syndrome in three (15%), and atrial fibrillation (AF) with a slow ventricular rate in four (20%). Predictors for PPM requirement by multivariate analysis were the presence of pulmonary hypertension (P-HTN), reoperation, and left bundle branch block (LBBB) (P < 0.05). Late follow-up was available in 18 patients, at 84.5 ± 30 months. Eleven patients (61%) were PPM dependent on long-term follow-up.

CONCLUSIONS

Patients at high risk for PPM implantation after cardiac surgery include those with P-HTN, reoperation, and pre-existing LBBB. Of those receiving a PPM, about one-third will recover at least partially at long-term follow-up. We recommend preoperative assessment for risk of requiring postoperative PPM, to counsel patients about this risk and early PPM implantation in high-risk patients who are PPM dependent after surgery.

摘要

背景

心脏手术后永久性起搏器(PPM)植入的患者比例为0.4%-6%,具体比例取决于心脏手术类型。术后早期植入PPM可能会降低发病率并缩短术后住院时间。我们对3年内接受冠状动脉旁路移植术(CABG)、瓣膜手术或两者皆有的成年患者的电子病历进行了回顾性研究。我们的目的是确定当前手术时代PPM需求的预测因素以及随访时对PPM的依赖情况。

方法

排除患有先天性心脏病、已植入PPM或植入式心脏复律除颤器(ICD)的患者以及术前有PPM或ICD植入指征的患者后,我们确定了2007年1月至2009年12月期间接受心脏手术的1234例成年患者。对电子病历和起搏器门诊数据进行了回顾性研究。

结果

患者的平均年龄为46.65±16岁,59%为男性。575例(46.6%)进行了CABG,263例(21.3%)进行了主动脉瓣置换,333例(27%)进行了二尖瓣置换,76例(6.2%)进行了三尖瓣置换。20例(1.6%)患者术后需要植入PPM。PPM植入的指征包括13例(65%)完全性房室传导阻滞、3例(15%)病态窦房结综合征以及4例(20%)伴有缓慢心室率的心房颤动(AF)。多因素分析显示,PPM需求的预测因素为肺动脉高压(P-HTN)、再次手术和左束支传导阻滞(LBBB)(P<0.05)。18例患者进行了晚期随访,随访时间为84.5±30个月。11例(61%)患者在长期随访中依赖PPM。

结论

心脏手术后有PPM植入高风险的患者包括患有P-HTN、需要再次手术以及术前存在LBBB的患者。在接受PPM植入的患者中,约三分之一在长期随访中至少会部分恢复。我们建议对术后需要PPM的风险进行术前评估,以便向患者告知此风险,并对术后依赖PPM的高危患者进行早期PPM植入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44f4/5295576/e08e89bb9796/cr-07-123-g002.jpg

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