Panchal Sunil K, Wanyonyi Stephen, Brown Lindsay
Institute for Agriculture and the Environment, University of Southern Queensland, QLD, Toowoomba, 4350, Australia.
School of Health and Wellbeing, University of Southern Queensland, QLD, Toowoomba, 4350, Australia.
Curr Hypertens Rep. 2017 Mar;19(3):10. doi: 10.1007/s11906-017-0701-x.
Trace metals play an important role in the proper functioning of carbohydrate and lipid metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while deficiency of these trace metals can cause disorders with metabolic and physiological imbalances. This article concentrates on three trace metals (selenium, vanadium, and chromium) that may play crucial roles in controlling blood glucose concentrations possibly through their insulin-mimetic effects. For these trace metals, the level of evidence available for their health effects as supplements is weak. Thus, their potential is not fully exploited for the target of metabolic syndrome, a constellation that increases the risk for cardiovascular disease and type 2 diabetes. Given that the prevalence of metabolic syndrome is increasing throughout the world, a simpler option of interventions with food supplemented with well-studied trace metals could serve as an answer to this problem. The oxidation state and coordination chemistry play crucial roles in defining the responses to these trace metals, so further research is warranted to understand fully their metabolic and cardiovascular effects in human metabolic syndrome.
微量金属在碳水化合物和脂质代谢的正常运作中发挥着重要作用。因此，一些微量金属对于维持体内平衡至关重要，而这些微量金属的缺乏会导致代谢和生理失衡紊乱。本文着重探讨三种微量金属（硒、钒和铬），它们可能通过模拟胰岛素的作用，在控制血糖浓度方面发挥关键作用。对于这些微量金属，作为补充剂对健康影响的现有证据水平较弱。因此，它们在代谢综合征这一增加心血管疾病和2型糖尿病风险的症候群目标上的潜力尚未得到充分开发。鉴于代谢综合征在全球的患病率不断上升，一种更简单的干预选择，即食用添加了经过充分研究的微量金属的食物，可能是解决这一问题的答案。氧化态和配位化学在确定对这些微量金属的反应中起着关键作用，因此有必要进行进一步研究，以全面了解它们在人类代谢综合征中的代谢和心血管影响。
