急性淋巴细胞白血病诊断时染色体检查结果的预后意义
Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis.
作者信息
Secker-Walker L M, Lawler S D, Hardisty R M
出版信息
Br Med J. 1978 Dec 2;2(6151):1529-30. doi: 10.1136/bmj.2.6151.1529.
Abstract
Chromosomes were studied on diagnostic bone-marrow samples from 39 children with acute lymphoblastic leukaemia (ALL). The patients were classified, according to the chromosomal characteristics of the major proportion of their leukaemia cells, into five categories; hyperdiploid, pseudodiploid, diploid, hypodiploid, and mixed. Patients in the hyperdiploid category had significantly longer first remissions than those in all other categories, and those in the pseudodiploid category had the shortest. Neither the absence of any normal cells nor the presence of detectable clones appeared to be an adverse feature. We suggest that the proportion of hyperdiploid cells, determined by conventional chromosomal staining techniques, may be used as an additional prognostic feature in childhood ALL.
摘要
对39例急性淋巴细胞白血病（ALL）患儿的诊断性骨髓样本进行了染色体研究。根据其白血病细胞主要比例的染色体特征，将患者分为五类：超二倍体、假二倍体、二倍体、亚二倍体和混合型。超二倍体类别的患者首次缓解期明显长于所有其他类别，而假二倍体类别的患者缓解期最短。正常细胞的缺失或可检测克隆的存在似乎都不是不利特征。我们建议，通过传统染色体染色技术确定的超二倍体细胞比例可作为儿童ALL的一个额外预后特征。
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