García-Sevilla J A, Ulibarri I, Ugedo L, Gutierrez M
Psychopharmacology (Berl). 1987;92(3):320-3. doi: 10.1007/BF00210837.
The inhibition of basal and forskolin-stimulated platelet adenylate cyclase activity by (-)adrenaline was studied in ten heroin addicts during spontaneous withdrawal. Both basal and forskolin-stimulated enzyme activities were increased during heroin withdrawal and the inhibitory effect induced by (-)adrenaline was potentiated with parallel shifts to the left of the concentration-effect curves. The number of binding sites for 3Hadrenaline in platelet membranes was also increased during withdrawal. Treatment with clonidine markedly attenuated the inhibitory effect induced by (-)adrenaline on platelet adenylate cyclase activity. The results indicate that the heroin withdrawal syndrome induces supersensitivity of the platelet alpha 2-adrenoceptor-adenylate cyclase system.
在十名海洛因成瘾者自然戒断期间，研究了（-）肾上腺素对基础状态及福斯高林刺激的血小板腺苷酸环化酶活性的抑制作用。在海洛因戒断期间，基础及福斯高林刺激的酶活性均升高，且（-）肾上腺素诱导的抑制作用增强，浓度-效应曲线平行左移。戒断期间血小板膜上[3H]（-）肾上腺素的结合位点数量也增加。可乐定治疗显著减弱了（-）肾上腺素对血小板腺苷酸环化酶活性的抑制作用。结果表明，海洛因戒断综合征诱导血小板α2-肾上腺素能受体-腺苷酸环化酶系统超敏。
