Wu Yun, Liu Fen, Adi Dilare, Yang Yi-Ning, Xie Xiang, Li Xiao-Mei, Ma Xiang, Fu Zhen-Yan, Huang Ying, Chen Bang-Dang, Shan Chun-Fang, Ma Yi-Tong
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.
Department of General Practice, First Affiliated Hospital of Xinjiang Medical University, Urumqi, P.R. China.
PLoS One. 2017 Feb 15;12(2):e0171791. doi: 10.1371/journal.pone.0171791. eCollection 2017.
Ethnic differences in non-invasive measurements of carotid atherosclerosis are being increasingly reported, but the association between carotid atherosclerosis and different subtypes of hypertension in adult populations is not fully understood in different ethnicities. We aimed to investigate the association of carotid atherosclerosis with different subtypes of hypertension in different ethnicities in Xinjiang, a northwestern province in China.
A total of 14,618 participants (5,757 Hans, 4,767 Uygurs, and 4,094 Kazakhs) from 26 villages of seven cities in Xinjiang were randomly selected from the Cardiovascular Risk Survey conducted during 2007 and 2010. A standard questionnaire, a physical examination and biochemical tests were employed.
The mean common carotid intima-media thickness (CIMT) for the 14,618 participants was 0.86±0.003 mm. The CIMT gradually increased with age. Men (0.92±0.005 mm) had a higher CIMT than women (0.81±0.004 mm). The Uygur participants (0.82±0.006 mm) had a lower CIMT than the Han (0.88±0.005 mm) and Kazakh participants (0.88±0.005 mm). The overall prevalences of carotid intimal thickening and carotid plaques were 12.4% and 9.7%, respectively. The prevalence of CIMT varied for the different subtypes of hypertension. Multivariate logistic regression analysis showed different risk factors for abnormal CIMT in different ethnicities. The associations between abnormal CIMT and the different subtypes of hypertension within different ethnic backgrounds were also different. The risk factors for abnormal CIMT included systolic-diastolic hypertension (SDH) in Han participants (OR: 1.323, 95% CI: 1.100-1.590), SDH (OR: 1.426, 95% CI: 1.160-1.753) and isolated-systolic hypertension (ISH) (OR: 1.844, 95% CI: 1.470-2.313) in Uygur participants, and isolated-diastolic hypertension (IDH) (OR: 1.536, 95% CI: 1.170-2.016) in Kazakh participants.
There was an ethnic difference in the prevalence of abnormal CIMT in Xinjiang, a northwestern province in China. The associations between abnormal CIMT and the subtypes of hypertension varied among the different ethnic groups. Among the studied populations, Han participants with SDH, Uygur participants with SDH and ISH, and Kazakh with IDH were more likely to suffer carotid atherosclerosis than those with other subtypes of hypertension. Participants with different ethnic backgrounds had different sets of risk factors for abnormal CIMT.
关于颈动脉粥样硬化非侵入性测量中的种族差异报道日益增多，但在不同种族的成年人群中，颈动脉粥样硬化与不同亚型高血压之间的关联尚未完全明确。我们旨在研究中国西北部省份新疆不同种族中颈动脉粥样硬化与不同亚型高血压之间的关联。
从2007年至2010年进行的心血管风险调查中，随机选取了新疆七个城市26个村庄的14618名参与者（5757名汉族、4767名维吾尔族和4094名哈萨克族）。采用了标准问卷、体格检查和生化检测。
14618名参与者的平均颈总动脉内膜中层厚度（CIMT）为0.86±0.003毫米。CIMT随年龄逐渐增加。男性（0.92±0.005毫米）的CIMT高于女性（0.81±0.004毫米）。维吾尔族参与者（0.82±0.006毫米）的CIMT低于汉族（0.88±0.005毫米）和哈萨克族参与者（0.88±0.005毫米）。颈动脉内膜增厚和颈动脉斑块的总体患病率分别为12.4%和9.7%。不同亚型高血压的CIMT患病率有所不同。多因素逻辑回归分析显示不同种族中CIMT异常的危险因素不同。不同种族背景下CIMT异常与不同亚型高血压之间的关联也不同。汉族参与者中CIMT异常的危险因素包括收缩期-舒张期高血压（SDH）（比值比：1.323，95%置信区间：1.100 - 1.590），维吾尔族参与者中的SDH（比值比：1.426，95%置信区间：1.160 - 1.753）和单纯收缩期高血压（ISH）（比值比：1.844，95%置信区间：1.470 - 2.313），哈萨克族参与者中的单纯舒张期高血压（IDH）（比值比：1.536，95%置信区间：1.170 - 2.016）。
在中国西北部省份新疆，CIMT异常的患病率存在种族差异。不同种族群体中CIMT异常与高血压亚型之间的关联各不相同。在研究人群中，患有SDH的汉族参与者、患有SDH和ISH的维吾尔族参与者以及患有IDH的哈萨克族参与者比患有其他亚型高血压的参与者更易患颈动脉粥样硬化。不同种族背景的参与者CIMT异常的危险因素各不相同。
