职业性接触农药和其他杀生物剂与甲状腺癌风险
Occupational exposure to pesticides and other biocides and risk of thyroid cancer.
作者信息
Zeng Fanhua, Lerro Catherine, Lavoué Jérôme, Huang Huang, Siemiatycki Jack, Zhao Nan, Ma Shuangge, Deziel Nicole C, Friesen Melissa C, Udelsman Robert, Zhang Yawei
机构信息
Chongqing Safety Engineering Institute, Chongqing University of Science and Technology, Chongqing, China.
Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
出版信息
Occup Environ Med. 2017 Jul;74(7):502-510. doi: 10.1136/oemed-2016-103931. Epub 2017 Feb 15.
OBJECTIVES
To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer.
METHODS
Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders.
RESULTS
Individuals who were occupationally ever exposed to biocides had an increased risk of thyroid cancer (OR=1.65, 95% CI 1.16 to 2.35), and the highest risk was observed for the high cumulative probability of exposure (OR=2.18, 95% CI 1.28 to 3.73). The observed associations were similar when we restricted to papillary thyroid cancer and well-differentiated thyroid cancer. Stronger associations were observed for thyroid microcarcinomas (tumour size ≤1 cm). No significant association was observed for occupational exposure to pesticides.
CONCLUSIONS
Our study provides the first evidence linking occupational exposure to biocides and risk of thyroid cancer. The results warrant further investigation.
目的
评估职业接触杀生物剂和杀虫剂与甲状腺癌风险之间的关联。
方法
利用2010 - 2011年在康涅狄格州开展的一项基于人群的病例对照研究数据，该研究纳入了462例甲状腺癌新发病例和498例对照，我们通过工作暴露矩阵研究了与职业接触杀生物剂和杀虫剂的关联。我们使用无条件逻辑回归模型来估计比值比（OR）和95%置信区间（CI），并对潜在混杂因素进行了调整。
结果
曾经职业接触杀生物剂的个体患甲状腺癌的风险增加（OR = 1.65，95%CI为1.16至2.35），暴露累积概率高时风险最高（OR = 2.18，95%CI为1.28至3.73）。当我们将分析局限于乳头状甲状腺癌和高分化甲状腺癌时，观察到的关联相似。对于甲状腺微小癌（肿瘤大小≤1厘米），观察到更强的关联。未观察到职业接触杀虫剂有显著关联。
结论
我们的研究提供了首个将职业接触杀生物剂与甲状腺癌风险联系起来的证据。这些结果值得进一步研究。
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