一项探索强迫症患者形态学变化与5-羟色胺转运体基因启动子区多态性（5-HTTLPR）之间关联的初步研究。
A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients.
作者信息
Honda Shinichi, Nakao Tomohiro, Mitsuyasu Hiroshi, Okada Kayo, Gotoh Leo, Tomita Mayumi, Sanematsu Hirokuni, Murayama Keitaro, Ikari Keisuke, Kuwano Masumi, Yoshiura Takashi, Kawasaki Hiroaki, Kanba Shigenobu
机构信息
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, Japan.
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
出版信息
Ann Gen Psychiatry. 2017 Jan 17;16:2. doi: 10.1186/s12991-017-0126-6. eCollection 2017.
BACKGROUND
Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables.
METHODS
We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs).
RESULTS
We found that relative to the HCs, the OCD patients showed significant decreased GM volume in the right hippocampus, and increased GM volume in the left precentral gyrus. 5-HTTLPR polymorphism in OCD patients had a statistical tendency of stronger effects on the right frontal pole than those in HCs.
CONCLUSIONS
Our results showed that the neuroanatomical changes of specific GM regions could be endophenotypes of 5-HTTLPR polymorphism in OCD.
背景
强迫症（OCD）的临床和药理学研究表明，血清素能系统参与其发病机制，而结构成像研究发现强迫症患者存在一些神经解剖学异常。在强迫症的病因发病机制中，很少有研究同时评估遗传和神经解剖学变量。
方法
我们对40名强迫症患者和40名健康对照者（HCs）的血清素转运体基因中的可变串联重复多态性（5-HTTLPR）和灰质（GM）体积进行了双向方差分析。
结果
我们发现，相对于健康对照者，强迫症患者右侧海马体的灰质体积显著减少，左侧中央前回的灰质体积增加。强迫症患者的5-HTTLPR多态性对右侧额极的影响比健康对照者有更强的统计学趋势。
结论
我们的结果表明，特定灰质区域的神经解剖学变化可能是强迫症中5-HTTLPR多态性的内表型。
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