抗CD20单克隆抗体治疗Q热相关性冷球蛋白血症的疗效
Resolution of Q Fever-Associated Cryoglobulinemia With Anti-CD20 Monoclonal Antibody Treatment.
作者信息
Hawkins Kellie L, Janoff Edward N, Janson Robert W
机构信息
University of Colorado, Aurora, CO, USA.
University of Colorado, Aurora, CO, USA; Denver Veterans Affairs Medical Center, Denver, CO, USA.
出版信息
J Investig Med High Impact Case Rep. 2017 Jan 1;5(1):2324709616686612. doi: 10.1177/2324709616686612. eCollection 2017 Jan-Mar.
Immunologic phenomena can complicate chronic infections with (Q fever), including immune complex deposition causing vasculitis, neuropathy, and glomerulonephritis. We describe the case of a man with Q fever endocarditis, mixed cryoglobulinemia, and life-threatening vasculitis driven by immune complex deposition who was successfully treated with B cell depleting therapy (rituximab).
免疫现象可使慢性感染（如Q热）复杂化，包括免疫复合物沉积导致血管炎、神经病变和肾小球肾炎。我们描述了一例患有Q热心内膜炎、混合性冷球蛋白血症以及由免疫复合物沉积驱动的危及生命的血管炎的男性患者，该患者通过B细胞清除疗法（利妥昔单抗）成功治愈。
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