维甲酸（E5166）对鼻咽杂交细胞生长的抑制作用及对丁酸钠诱导爱泼斯坦-巴尔病毒早期抗原的抑制作用。

Inhibitory effect of retinoid (E5166) on cell growth and suppressive effect on Epstein-Barr virus early-antigen induction by n-butyrate in nasopharyngeal hybrid cells.

作者信息

Furukawa M, Umeda R

出版信息

Auris Nasus Larynx. 1987;14(1):39-45. doi: 10.1016/s0385-8146(87)80007-x.

PMID:2820366

Abstract

The in vitro proliferation and colony-forming activity (plating efficiency) of Epstein-Barr virus (EBV) nuclear antigen-positive nasopharyngeal hybrid cells were inhibited by one of the retinoid, polyprenoic acid; E5166. It was dependent on retinoid concentration. Furthermore, an induction of EBV early antigen after treatment with 4 mM n-butyrate was markedly suppressed by E5166 and this was similar to the previously reported effects of retinoid acid on iododeoxyuridine (IUDR) and 12-O-tetra-decanoyl-phorbol-13-acetate (TPA) induction. These results support to lead a clinical application of E5166 for combination chemotherapy in patients with nasopharyngeal carcinoma.

摘要

类视黄醇多聚戊烯酸E5166可抑制爱泼斯坦-巴尔病毒（EBV）核抗原阳性的鼻咽杂交细胞的体外增殖和集落形成活性（接种效率）。这取决于类视黄醇的浓度。此外，E5166可显著抑制用4 mM正丁酸盐处理后EBV早期抗原的诱导，这与先前报道的视黄酸对碘脱氧尿苷（IUDR）和12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的作用相似。这些结果支持E5166在鼻咽癌患者联合化疗中的临床应用。