化学诱导剂对上皮/鼻咽癌杂交细胞系中爱泼斯坦-巴尔病毒周期的影响。
Effects of chemical inducers on the Epstein-Barr virus cycle in epithelial/nasopharyngeal carcinoma hybrid cell line.
作者信息
Takimoto T, Ishiguro H, Umeda R, Ogura H, Hatano M
出版信息
ORL J Otorhinolaryngol Relat Spec. 1984;46(4):192-4. doi: 10.1159/000275708.
PMID:6087237
Abstract
We have studied the induction of Epstein-Barr virus (EBV)-specific antigens in nasopharyngeal carcinoma hybrid cells by treatment with the tumor promotor 12-0-tetradecanoylphorbol-13-acetate (TPA), hydrogen peroxide (H2O2) and n-butyric acid. The intensity of EBV induction by these drugs was in the order of n-butyric acid----TPA----H2O2. Furthermore, the combination of H2O2 or TPA and n-butyric acid acted synergistically on EBV-induced antigens.
摘要
我们研究了用肿瘤促进剂十四酰佛波醇乙酯（TPA）、过氧化氢（H2O2）和正丁酸处理鼻咽癌杂交细胞后，爱泼斯坦-巴尔病毒（EBV）特异性抗原的诱导情况。这些药物诱导EBV的强度顺序为正丁酸----TPA----H2O2。此外，H2O2或TPA与正丁酸联合使用对EBV诱导抗原具有协同作用。
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