一种新型CD206+巨噬细胞特异性动脉成像策略在HIV感染个体中的应用。
Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals.
作者信息
Zanni Markella V, Toribio Mabel, Wilks Moses Q, Lu Michael T, Burdo Tricia H, Walker Joshua, Autissier Patrick, Foldyna Borek, Stone Lauren, Martin Amanda, Cope Fred, Abbruzzese Bonnie, Brady Thomas, Hoffmann Udo, Williams Kenneth C, El-Fakhri Georges, Grinspoon Steven K
机构信息
Program in Nutritional Metabolism and.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston.
出版信息
J Infect Dis. 2017 Apr 15;215(8):1264-1269. doi: 10.1093/infdis/jix095.
BACKGROUND
The ability to noninvasively assess arterial CD206+ macrophages may lead to improved understanding of human immunodeficiency virus (HIV)-associated cardiovascular disease.
METHODS
We trialed a novel macrophage-specific arterial imaging technique.
RESULTS
We demonstrated colocalization between technetium Tc 99m tilmanocept (99mTc-tilmanocept) and CD206+ macrophages ex vivo. In vivo application of 99mTc-tilmanocept single-photon emission computed tomography/computed tomography revealed high-level 99mTc-tilmanocept uptake across 20.4% of the aortic surface volume among HIV-infected subjects, compared with 4.3% among non-HIV-infected subjects (P = .009). Among all subjects, aortic high-level 99mTc-tilmanocept uptake was related to noncalcified aortic plaque volume (r = 0.87; P = .003) on computed tomographic angiography, and this relationship held when we controlled for HIV status.
CONCLUSION
These first-in-human data introduce a novel macrophage-specific arterial imaging technique in HIV.
CLINICAL TRIALS REGISTRATION
NCT02542371.
背景
无创评估动脉CD206 +巨噬细胞的能力可能有助于增进对人类免疫缺陷病毒（HIV）相关心血管疾病的理解。
方法
我们试用了一种新型的巨噬细胞特异性动脉成像技术。
结果
我们在体外证明了锝Tc 99m替莫西肽（99mTc-替莫西肽）与CD206 +巨噬细胞的共定位。99mTc-替莫西肽单光子发射计算机断层扫描/计算机断层扫描的体内应用显示，HIV感染受试者中20.4%的主动脉表面体积有高水平的99mTc-替莫西肽摄取，而非HIV感染受试者中这一比例为4.3%（P = 0.009）。在所有受试者中，计算机断层血管造影显示主动脉高水平的99mTc-替莫西肽摄取与非钙化主动脉斑块体积相关（r = 0.87；P = 0.003），并且在我们控制HIV状态时这种关系依然成立。
结论
这些首次人体试验数据引入了一种用于HIV的新型巨噬细胞特异性动脉成像技术。
临床试验注册
NCT02542371。
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