Sameshima Y, Uchimura M, Muto Y, Maeda J, Tsuchiyama H
Second Department of Pathology, Nagasaki University School of Medicine, Japan.
Cancer. 1987 Oct 15;60(8):1883-90. doi: 10.1002/1097-0142(19871015)60:8<1883::aid-cncr2820600835>3.0.co;2-x.
From 1972 to 1985, 40 cases of congenital dilatation of the bile duct (CDBD) were experienced in the department of the authors. Those consisted of 19 cases of anomalous arrangement of the pancreatico-bile duct (P-B anomaly), five of bile duct carcinoma, and two of gall bladder carcinoma. In addition, four patients who showed no dilatation of the bile duct in spite of the presence of a P-B anomaly were experienced, and coexistent gall bladder carcinoma was present in three of four cases. The incidence of bile duct carcinoma associated with CDBD is very high. However, coexistent gall bladder carcinoma in CDBD is a new topic, and coexistent intrahepatic bile duct carcinoma in CDBD is extremely rare. This report presents interesting and rare cases of coexistent carcinomas in these anomalies and investigates their carcinogenesis, particularly that of gall bladder carcinoma.
1972年至1985年，作者所在科室共收治40例先天性胆管扩张症（CDBD）。其中包括19例胰胆管异常排列（P - B异常）、5例胆管癌和2例胆囊癌。此外，还遇到4例尽管存在P - B异常但胆管未扩张的患者，其中3例合并胆囊癌。与CDBD相关的胆管癌发病率非常高。然而，CDBD合并胆囊癌是一个新课题，而CDBD合并肝内胆管癌极为罕见。本报告展示了这些异常情况中合并癌的有趣且罕见的病例，并探讨了它们的致癌机制，特别是胆囊癌的致癌机制。
