Kinoshita H, Nagata E, Hirohashi K, Sakai K, Kobayashi Y
Cancer. 1984 Aug 15;54(4):762-9. doi: 10.1002/1097-0142(1984)54:4<762::aid-cncr2820540429>3.0.co;2-k.
During the last 8 years, the authors had experience with 10 cases of carcinoma of the gallbladder with an anomalous connection between the choledochus and the pancreatic duct. These cases were studied in reference to age, sex, frequency of gallstones and dilatation of the bile duct, amylase levels in bile, direct cholangiograms, histologic findings, methods of treatment, and prognosis. Histologically, intestinal metaplasia was noticed in cancerous areas and also in noncancerous areas of differentiated adenocarcinomas. These facts suggest that in carcinoma of the gallbladder with this anomaly, reflux and stasis of pancreatic juice in the gallbladder may induce chronic cholecystitis which leads to mucosal metaplasia and, eventually, to differentiated adenocarcinoma.
在过去8年中，作者遇到10例胆总管与胰管存在异常连接的胆囊癌病例。对这些病例进行了年龄、性别、胆结石发生率、胆管扩张情况、胆汁中的淀粉酶水平、直接胆管造影、组织学检查结果、治疗方法及预后等方面的研究。组织学检查发现，在分化型腺癌的癌灶及非癌灶区域均可见肠化生。这些事实表明，对于存在这种异常的胆囊癌，胆囊内胰液的反流和淤滞可能诱发慢性胆囊炎，进而导致黏膜化生，最终发展为分化型腺癌。
