灭活猫逆转录病毒对猫α干扰素和免疫球蛋白产生的影响。
Influence of inactivated feline retrovirus on feline alpha interferon and immunoglobulin production.
作者信息
Yasuda M, Good R A, Day N K
机构信息
All Children's Hospital, University of South Florida, St Petersburg.
出版信息
Clin Exp Immunol. 1987 Aug;69(2):240-5.
The effect of ultraviolet-inactivated feline leukaemia virus (UV-FeLV) on the development of feline immunoglobulin-secreting cells (ISC) was investigated using a reverse haemolytic plaque assay. Low concentrations of UV-FeLV at 2 X 10(-4) to 2.0 micrograms/ml stimulated the production of ISC. By contrast, the same concentration of UV-FeLV suppressed the development of pokeweed mitogen (PWM)-driven ISC. Maximum suppression of ISC occurred at 50 micrograms/ml of UV-FeLV. The generation of an interferon resistant to acid, heat and sodium dodecyl sulphate (SDS) in the media of lymphocyte cultures incubated with PWM was also significantly suppressed in the presence of 0.2 microgram/ml of UV-FeLV. These findings suggest that non-infectious viral particles appear to modify feline immunoglobulin and interferon-secreting systems.
采用反向溶血空斑试验研究了紫外线灭活的猫白血病病毒（UV-FeLV）对猫免疫球蛋白分泌细胞（ISC）发育的影响。浓度为2×10⁻⁴至2.0微克/毫升的低浓度UV-FeLV刺激了ISC的产生。相比之下，相同浓度的UV-FeLV抑制了商陆有丝分裂原（PWM）驱动的ISC的发育。在50微克/毫升的UV-FeLV时，ISC受到最大抑制。在存在0.2微克/毫升UV-FeLV的情况下，与PWM一起孵育的淋巴细胞培养物培养基中对酸、热和十二烷基硫酸钠（SDS）具有抗性的干扰素的产生也受到显著抑制。这些发现表明，非感染性病毒颗粒似乎会改变猫免疫球蛋白和干扰素分泌系统。
Zotero 插件