Hossmann K A
Max-Planck-Institute for Neurological Research, Department of Experimental Neurology, Cologne, FRG.
Gerontology. 1987;33(3-4):213-9. doi: 10.1159/000212880.
The potentials of postischemic functional recovery were studied in cats submitted to 1 h of complete cerebrocirculatory arrest in normothermia. Neuronal activity was estimated by recording the electroencephalogram (EEG), the pyramidal response following stimulation of the motor cortex and the somatosensorily evoked cortical potentials. During ischemia EEG was suppressed within 12-15 s, evoked potentials within 2 min, and the pyramidal response within 5 min. After recirculation following ischemia, the electrically evoked D wave of the pyramidal response began to reappear between 7 and 9 min and the synaptically evoked I wave between 25 and 60 min. The evoked cortical potentials returned in parallel with the I wave of the pyramidal response but control amplitude was not reached before 3 h. The peak latencies of the evoked potentials were consistently prolonged for at least 24 h but normalized after a few days, provided secondary postischemic circulatory disturbances could be prevented. EEG began to recover after the beginning appearance of the somatosensorily evoked cortical potentials; initially it exhibited a burst-suppression pattern but it gradually progressed to continuous activity. The frequency pattern of the EEG normalized within 24 h and the amplitude after a few days. After recovery, the behavior of the pyramidal response and of evoked potentials to repetitive stimulation was the same as under control conditions.
在体温正常的猫身上进行了1小时完全脑循环停止的实验，研究了缺血后功能恢复的潜力。通过记录脑电图（EEG）、刺激运动皮层后的锥体反应以及体感诱发电位来评估神经元活动。在缺血期间，脑电图在12 - 15秒内被抑制，诱发电位在2分钟内被抑制，锥体反应在5分钟内被抑制。缺血后再灌注时，锥体反应的电诱发D波在7 - 9分钟之间开始重新出现，突触诱发的I波在25 - 60分钟之间出现。诱发电位与锥体反应的I波同时恢复，但在3小时之前未达到对照振幅。诱发电位的峰值潜伏期持续延长至少24小时，但如果能预防继发性缺血后循环障碍，几天后潜伏期会恢复正常。在体感诱发电位开始出现后，脑电图开始恢复；最初表现为爆发抑制模式，但逐渐发展为持续活动。脑电图的频率模式在24小时内恢复正常，振幅在几天后恢复正常。恢复后，锥体反应和对重复刺激的诱发电位的行为与对照条件下相同。
