Hossmann K A
Max-Planck Institute für Nerologische Forschung, Abteilung für Experimentelle Neurologie, Cologne, West Germany.
Crit Care Med. 1988 Oct;16(10):964-71. doi: 10.1097/00003246-198810000-00007.
Predictors of postischemic recovery were determined in adult cats subjected to one hour of global brain ischemia followed by blood recirculation for 3 h or longer. The incidence of postischemic recovery of evoked potentials and of spontaneous EEG activity was determined and related to the following variables: anesthesia (barbiturate or halothane/nitrous oxide), completeness of ischemia, body temperature, plasma glucose, arterial pH, blood gases, blood osmolality, postischemic BP, and cerebral blood flow (CBF). The closest correlation was obtained with the rate of initial postischemic recirculation; CBF above 40 ml/100 g.min resulted almost consistently in EEG recovery. Temperature, arterial pH, plasma glucose, and osmolality also influenced recovery. There was no correlation of EEG recovery with blood gases nor improvement of recovery after incomplete ischemia or barbiturate anesthesia. The results are interpreted in respect to common concepts of ischemic injury and the treatment of postischemic resuscitation disease.
在成年猫身上确定了缺血后恢复的预测因素，这些猫经历了1小时的全脑缺血，随后进行3小时或更长时间的血液再灌注。测定了诱发电位和自发脑电图活动缺血后恢复的发生率，并将其与以下变量相关联：麻醉（巴比妥类或氟烷/氧化亚氮）、缺血的完整性、体温、血浆葡萄糖、动脉pH值、血气、血液渗透压、缺血后血压和脑血流量（CBF）。与缺血后初始再灌注速率的相关性最为密切；脑血流量高于40 ml/100 g·min几乎始终导致脑电图恢复。体温、动脉pH值、血浆葡萄糖和渗透压也影响恢复。脑电图恢复与血气无关，不完全缺血或巴比妥类麻醉后恢复也无改善。根据缺血性损伤的常见概念和缺血后复苏疾病的治疗对结果进行了解释。
