Wang An-Dong, Xie Chao-Jie, Zhang Yun-Qiang, Li Mei-Chen, Wang Xia, Liu Jian-Yu, Xu Yong-Nan
School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Planta Med. 2019 Mar;85(4):335-339. doi: 10.1055/a-0832-2328. Epub 2019 Jan 28.
Two new -tetralonyl glucosides, (4)-4,5,8-trihydroxy--tetralone-5---D-glucopyranosyl(1 → 6)--D-glucopyranoside (1: ) and (4)-4,8-dihydroxy--tetralone-4---D-glucopyranosyl(1 → 6)--D-glucopyranoside (2: ), together with eight known compounds (3: - 10: ) were isolated from the green walnut husks of . The structural characterization of all compounds was performed by spectroscopic analyses, including 1D and 2D NMR and HR-ESI-MS experiments. The isolated compounds were assayed for their cytotoxicity against two human cancer cell lines, A549 and HeLa. Four compounds (7: - 10: ) exhibited inhibitory effects against two human cancer cell lines with GI values between 1.3 and 5.8 µM.
从胡桃的绿胡桃壳中分离出两种新的 - 四氢萘酮基葡萄糖苷，即(4)-4,5,8-三羟基 - - 四氢萘酮 - 5 - -D-吡喃葡萄糖基(1→6)--D-吡喃葡萄糖苷(1: )和(4)-4,8-二羟基 - - 四氢萘酮 - 4 - -D-吡喃葡萄糖基(1→6)--D-吡喃葡萄糖苷(2: )，以及八种已知化合物(3: - 10: )。所有化合物的结构表征通过光谱分析进行，包括一维和二维核磁共振以及高分辨电喷雾电离质谱实验。对分离出的化合物针对两种人类癌细胞系A549和HeLa进行了细胞毒性测定。四种化合物(7: - 10: )对两种人类癌细胞系表现出抑制作用，生长抑制值在1.3至5.8 μM之间。
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