Huerter Christopher J, Vaudreuil Adam, Agrawal Devendra K, Nguyen Austin Huy
Division of Dermatology and Department of Clinical and Translational Science, Creighton University School of Medicine, Omaha, Nebraska.
J Clin Aesthet Dermatol. 2016 Dec;9(12):11-12. Epub 2016 Dec 1.
Growing evidence suggests a pivotal role for vitamin D in cancers, particularly melanoma. The broad immunologic effects of vitamin D and its signaling axis make for a complex interplay between tumor cells and the immune system. Preclinical evidence suggests vitamin D to have protective effects in melanoma oncogenesis and progression, creating a potential role for vitamin D supplementation in cancer prevention and/or adjuvant therapy. In this commentary, the authors highlight studies of vitamin D in melanoma with clinical implications and call for large clinical trials to definitively determine the role of supplementation in patients to prevent and help treat melanoma.
越来越多的证据表明维生素D在癌症，尤其是黑色素瘤中起关键作用。维生素D及其信号轴广泛的免疫效应导致肿瘤细胞与免疫系统之间产生复杂的相互作用。临床前证据表明维生素D在黑色素瘤的发生和进展中具有保护作用，这为补充维生素D在癌症预防和/或辅助治疗中创造了潜在作用。在这篇评论中，作者强调了维生素D在黑色素瘤方面具有临床意义的研究，并呼吁开展大型临床试验以明确确定补充维生素D在预防和帮助治疗黑色素瘤患者中的作用。
