Denzer Nicole, Vogt Thomas, Reichrath Jörg
Department of Dermatology; The Saarland University Hospital; Homburg, Germany.
Dermatoendocrinol. 2011 Jul;3(3):205-10. doi: 10.4161/derm.3.3.16519. Epub 2011 Jul 1.
Skin cancer is the most common cancer in humans. There are several types of skin cancer that include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). The associations of vDr polymorphisms with skin cancer risk are not well characterized so far. Only a few epidemiologic studies have directly addressed the relationship between VDR polymorphisms and the incidence and prognosis of MM. To make the most of the available information on VDR polymorphisms and skin cancer (MM, BCC and SCC), we undertook a systematic review of published studies. In conclusion, data summarized in this review support the concept that the vitamin D endocrine system (VDES) is of importance for pathogenesis and progression of MM and other types of skin cancer.
皮肤癌是人类最常见的癌症。皮肤癌有几种类型，包括基底细胞癌（BCC）、鳞状细胞癌（SCC）和恶性黑色素瘤（MM）。迄今为止，维生素D受体（vDr）多态性与皮肤癌风险之间的关联尚未得到充分表征。只有少数流行病学研究直接探讨了VDR多态性与MM发病率和预后之间的关系。为了充分利用有关VDR多态性和皮肤癌（MM、BCC和SCC）的现有信息，我们对已发表的研究进行了系统综述。总之，本综述总结的数据支持维生素D内分泌系统（VDES）对MM和其他类型皮肤癌的发病机制和进展具有重要意义这一概念。
