Kaur Jasleen, Raval Rushik, Bansal Anupam, Kumawat Vinod
Postgraduate student, Dept of Oral and maxillofacial surgery, Maharaja Ganga Singh Dental College and Research Centre, 11, LNP, Hanumangarhroad, Near RICCO, Sri Ganganagar, Rajasthan, India.
Assistant Professor, department of oral and maxillofacial surgery, Darshan Dental college, Udaipur.
J Clin Exp Dent. 2017 Feb 1;9(2):e284-e288. doi: 10.4317/jced.53262. eCollection 2017 Feb.
To evaluate the effects of intraalveolar placement of gel containing 0.2% chlorhexidine and 10gm of metronidazole on the incidence of alveolar osteitis.
A total of 300 impacted third molars were extracted in 150 patients enrolled in this trial. In each subject a socket was randomly selected and packed to the crest of alveolar ridge with the gel. The contralateral socket was packed with placebo dressing. The occurrence of dry socket was assessed during 3rd and 5th postoperative days .The data was analysed using a meta analytical program.
Double blind, prospective, placebo controlled trial.
The combination of metronidazole + chlorhexidine gel significantly reduced dry socket incidence from 22.6% to 6.6% ( ≤ 0.001) [McNemar and chi-square tests].
The decrease in incidence of adverse reactions and complications related to local application of metronidazole and chlorhexidine gel explains its clinical use, specifically in mandibular molar extractions where the chances of dry sockets are high. Chlorhexidine, dry socket, intra-alveolar, metronidazole, placebo.
评估牙槽窝内放置含0.2%氯己定和10克甲硝唑的凝胶对牙槽骨炎发生率的影响。
本试验纳入150例患者，共拔除300颗阻生第三磨牙。在每个受试者中，随机选择一个牙槽窝并用该凝胶填充至牙槽嵴顶。对侧牙槽窝用安慰剂敷料填充。在术后第3天和第5天评估干槽症的发生情况。使用荟萃分析程序对数据进行分析。
双盲、前瞻性、安慰剂对照试验。
甲硝唑+氯己定凝胶联合使用显著降低了干槽症发生率，从22.6%降至6.6%（≤0.001）[麦克内马尔检验和卡方检验]。
甲硝唑和氯己定凝胶局部应用相关不良反应和并发症发生率的降低解释了其临床应用，特别是在下颌磨牙拔除术中，干槽症发生几率较高的情况下。氯己定、干槽症、牙槽窝内、甲硝唑、安慰剂。
