Margaix-Muñoz Maria, Bagán José, Poveda-Roda Rafael
DDS, PhD. Associate Professor of Oral Medicine. Department of Stomatology, University of Valencia. Valencia (Spain).
MD, DDS, PhD. Charmain of Oral Medicine. Department of Stomatology, University of Valencia. Head of Stomatology and Maxillofacial Surgery Service. General Universitary Hospital of Valencia. Valencia (Spain).
J Clin Exp Dent. 2017 Feb 1;9(2):e294-e301. doi: 10.4317/jced.53575. eCollection 2017 Feb.
A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity.
A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operators were used: Ewing AND Sarcoma AND [tongue, jaw, maxilla, cheek, condyle OR temporomandibular, floor AND mouth, gum OR gingiva, palate OR palatal, lip, uvula, head AND neck].
Seventy-one cases of ES of the oral cavity were documented from 53 articles. The main differences versus ES of other locations were a younger age at manifestation, a shorter time from symptoms onset to diagnosis, and swelling as the most frequent clinical manifestation versus swelling and pain in the rest of disease locations. The way in which ES manifests in the oral cavity is varied and comprises dental displacement (19.7%), dental mobility (7%), root reabsorption (5.6%), destruction of the dental follicle (4.2%), premature exfoliation (4.2%) and paresthesia of the chin (2.8%). Metastatic neck adenopathies appear in 11.3% of the cases. Significant differences in survival are observed between patients with a complete diagnosis of ES (hematoxylin-eosin staining, PAS positivity, CD99 positivity) and those with an incomplete diagnosis.
Ewing sarcoma of the oral cavity presents a series of specific features that distinguish it from ES of other locations. Primitive neuroectodermal tumor, PNET, Ewing sarcoma, Ewing tumor, sarcoma, oral cavity.
对口腔尤因肉瘤（ES）的临床、诊断、治疗及生存特征进行综述。
进行系统的文献检索，限制条件包括时间（1960 - 2014年）、语言（英语和西班牙语）及研究类型（病例报告、信函、数据集、综述）。使用了以下医学主题词和布尔运算符：尤因肉瘤与肉瘤与[舌、颌骨、上颌骨、颊部、髁突或颞下颌关节、口腔底部、牙龈或齿龈、腭部或腭、唇、悬雍垂、头颈部]。
从53篇文章中记录了71例口腔ES病例。与其他部位的ES相比，主要差异在于发病年龄更小、从症状出现到诊断的时间更短，以及肿胀是最常见的临床表现，而其他疾病部位则是肿胀和疼痛。ES在口腔中的表现形式多样，包括牙齿移位（19.7%）、牙齿松动（7%）、牙根吸收（5.6%）、牙囊破坏（4.2%）、过早脱落（4.2%）和颏部感觉异常（2.8%）。11.3%的病例出现转移性颈部淋巴结病。在完全诊断为ES（苏木精 - 伊红染色、PAS阳性、CD99阳性）的患者与诊断不完全的患者之间观察到生存存在显著差异。
口腔尤因肉瘤呈现出一系列使其有别于其他部位ES的特定特征。原始神经外胚层肿瘤、PNET、尤因肉瘤、尤因瘤、肉瘤、口腔。
