Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Phytother Res. 2017 Apr;31(4):647-656. doi: 10.1002/ptr.5778. Epub 2017 Feb 16.
Benign prostate hyperplasia (BPH) is a progressive disease that is related to age. Known therapeutic agents used in the treatment of BPH are associated with toxicity. Therefore, chemoprevention could be an effective approach. We investigated the ameliorative effects of methyl jasmonate (MeJA) in testosterone propionate (TP)-induced BPH in castrated rats. Castration was performed by removing both testes through the scrotum sack under ketamine anesthesia. Rats were assigned into seven groups of seven animals each: non-castrated control, castrated control, castrated rats that received TP, castrated rats that received TP and MeJA, castrated rats that received TP and finasteride, castrated rats that received MeJA, and castrated rats that received finasteride. Results indicate that BPH rats had significantly (p < 0.05) elevated prostate weight and relative weight of prostate relative to control. Also, BPH rats had significantly (p < 0.05) increased activities of prostatic acid and alkaline phosphatases, levels of zinc, and malondialdehyde. Further, levels of enzymic and non-enzymic antioxidative indices were significantly (p < 0.05) reduced in BPH. Histology of prostate revealed hyperplasia of transition lobe, increased expression of PSA, and Ki67 in BPH. Treatment with MeJA and finasteride attenuated the activities of the phosphatases and levels of antioxidants in BPH. Overall, MeJA ameliorates BPH via antioxidative mechanism. Copyright © 2017 John Wiley & Sons, Ltd.
良性前列腺增生症（BPH）是一种与年龄相关的进行性疾病。用于治疗 BPH 的已知治疗药物与毒性有关。因此，化学预防可能是一种有效的方法。我们研究了茉莉酸甲酯（MeJA）在丙酸睾酮（TP）诱导的去势大鼠 BPH 中的改善作用。通过在氯胺酮麻醉下通过阴囊切除双侧睾丸进行去势。将大鼠分为七组，每组 7 只：非去势对照组、去势对照组、去势大鼠接受 TP、去势大鼠接受 TP 和 MeJA、去势大鼠接受 TP 和非那雄胺、去势大鼠接受 MeJA 和去势大鼠接受非那雄胺。结果表明，BPH 大鼠的前列腺重量和前列腺相对重量明显（p<0.05）升高。此外，BPH 大鼠的前列腺酸性和碱性磷酸酶活性、锌水平和丙二醛水平明显（p<0.05）升高。此外，BPH 大鼠的酶和非酶抗氧化指标水平明显（p<0.05）降低。前列腺组织学显示过渡叶增生、PSA 和 Ki67 在 BPH 中表达增加。用 MeJA 和非那雄胺治疗可减弱 BPH 中磷酸酶的活性和抗氧化剂的水平。总的来说，MeJA 通过抗氧化机制改善 BPH。版权所有 © 2017 约翰威立父子公司
