Institut Curie, PSL Research University, CNRS UMR144, F-75005 Paris, France.
Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.
Curr Opin Cell Biol. 2018 Feb;50:94-101. doi: 10.1016/j.ceb.2018.03.002. Epub 2018 Mar 19.
At the center of the secretory pathway, the Golgi complex ensures correct processing and sorting of cargos toward their final destination. Cargos are diverse in topology, function and destination. A remarkable feature of the Golgi complex is its ability to sort and process these diverse cargos destined for secretion, the cell surface, the lysosome, or retained within the secretory pathway. Just as these cargos are diverse so also are their sorting requirements and thus, their trafficking route. There is no one-size-fits-all sorting scheme in the Golgi. We propose a coexistence of models to reconcile these diverse needs. We review examples of differential sorting mediated by proteins and lipids. Additionally, we highlight recent technological developments that have potential to uncover new modes of transport.
在分泌途径的中心，高尔基体复合体确保了货物向其最终目的地的正确处理和分拣。货物在拓扑结构、功能和目的地方面存在多样性。高尔基体复合体的一个显著特点是它能够对这些不同的货物进行分拣和加工，这些货物的目的地包括分泌、细胞膜表面、溶酶体或在分泌途径中被保留。就像这些货物具有多样性一样，它们的分拣要求也不同，因此它们的运输路线也不同。高尔基体中没有一种适用于所有情况的分拣方案。我们提出了共存模型来协调这些不同的需求。我们回顾了由蛋白质和脂质介导的差异分拣的例子。此外，我们还强调了一些新技术的发展，这些技术有可能揭示新的运输方式。
