Kuriyama Nagato, Inaba Masaaki, Ozaki Etsuko, Yoneda Yutaro, Matsui Daisuke, Hashiguchi Kanae, Koyama Teruhide, Iwai Komei, Watanabe Isao, Tanaka Rika, Omichi Chie, Mizuno Shigeto, Kurokawa Masao, Horii Motoyuki, Niwa Fumitoshi, Iwasa Koichi, Yamada Shinsuke, Watanabe Yoshiyuki
Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Department of Metabolism, Endocrinology, and Molecular Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Arch Gerontol Geriatr. 2017 May-Jun;70:201-208. doi: 10.1016/j.archger.2017.02.005. Epub 2017 Feb 10.
Sleep has been reported to be an important factor in bone metabolism, and sympathetic nervous system activity has been reported to regulate bone metabolism. In this study, we evaluated the association between sleep, sympathetic nervous system activity, and bone mass.
The study subjects were 221 individuals (108 males; 113 females; mean age: 55.1±7.0years) divided into two groups: those who slept for less than 6h a day (short sleep [SS] group), and those who slept 6h or longer (normal sleep [NS] group). The groups were compared with regard to lifestyle, cortical bone thickness, cancellous bone density, bone metabolism markers, blood leptin levels, and sympathetic nervous system activity as evaluated by heart rate variability analysis.
Significant differences were observed between the two groups in cortical bone thickness, blood TRACP-5b, and leptin levels. The L/H ratio (an index of sympathetic nervous system activity) was higher in the SS group than in the NS group. Significant negative correlations were observed between cortical bone thickness and both the L/H ratio and leptin levels, and a significant positive correlation was observed between the L/H ratio and leptin levels.
Short sleep was associated with a decline in cortical bone thickness due to the promotion of bone resorption and sympathetic nervous system hyperactivity in the middle-aged group. Leptin levels and cortical bone thickness were found to be closely related, suggesting that cortical bone mass may be regulated via interaction with the leptin-sympathetic nervous system.
据报道，睡眠是骨代谢的一个重要因素，且据报道交感神经系统活动可调节骨代谢。在本研究中，我们评估了睡眠、交感神经系统活动与骨量之间的关联。
研究对象为221人（男性108名；女性113名；平均年龄：55.1±7.0岁），分为两组：每天睡眠时间少于6小时的人群（短睡眠[SS]组）和睡眠时间为6小时或更长时间的人群（正常睡眠[NS]组）。比较两组在生活方式、皮质骨厚度、松质骨密度、骨代谢标志物、血液瘦素水平以及通过心率变异性分析评估的交感神经系统活动方面的差异。
两组在皮质骨厚度、血液抗酒石酸酸性磷酸酶5b（TRACP-5b）和瘦素水平方面存在显著差异。SS组的L/H比值（交感神经系统活动指标）高于NS组。皮质骨厚度与L/H比值及瘦素水平之间均存在显著负相关，且L/H比值与瘦素水平之间存在显著正相关。
在中年人群中，短睡眠与皮质骨厚度下降有关，这是由于骨吸收增加和交感神经系统功能亢进所致。发现瘦素水平与皮质骨厚度密切相关，提示皮质骨量可能通过与瘦素-交感神经系统的相互作用来调节。
