Hamm Lisa, Chen Zidong, Li Jinrong, Black Joanna, Dai Shuan, Yuan Junpeng, Yu Minbin, Thompson Benjamin
School of Optometry and Vision Science, University of Auckland, New Zealand.
State Key Laboratory of Ophthalmology, Guangdong Provincial Key Lab of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
Vision Res. 2017 Apr;133:112-120. doi: 10.1016/j.visres.2017.01.004. Epub 2017 Mar 30.
In patients with anisometropic or strabismic amblyopia, interocular suppression can be minimized by presenting high contrast stimulus elements to the amblyopic eye and lower contrast elements to the fellow eye. This suggests a structurally intact binocular visual system that is functionally suppressed. We investigated whether suppression can also be overcome by contrast balancing in children with deprivation amblyopia due to childhood cataracts. To quantify interocular contrast balance, contrast interference thresholds were measured using an established dichoptic global motion technique for 21 children with deprivation amblyopia, 14 with anisometropic or mixed strabismic/anisometropic amblyopia and 10 visually normal children (mean age mean=9.9years, range 5-16years). We found that interocular suppression could be overcome by contrast balancing in most children with deprivation amblyopia, at least intermittently, and all children with anisometropic or mixed anisometropic/strabismic amblyopia. However, children with deprivation amblyopia due to early unilateral or bilateral cataracts could tolerate only very low contrast levels to the stronger eye indicating strong suppression. Our results suggest that treatment options reliant on contrast balanced dichoptic presentation could be attempted in a subset of children with deprivation amblyopia.
在屈光参差性或斜视性弱视患者中，通过向弱视眼呈现高对比度刺激元素，向对侧眼呈现低对比度元素，可以将双眼间抑制降至最低。这表明存在一个结构完整但功能上受到抑制的双眼视觉系统。我们研究了在因儿童白内障导致的剥夺性弱视儿童中，是否也可以通过对比度平衡来克服抑制。为了量化双眼间的对比度平衡，我们使用一种既定的双眼全局运动技术，对21名剥夺性弱视儿童、14名屈光参差性或斜视性/屈光参差性混合弱视儿童以及10名视力正常儿童（平均年龄=9.9岁，范围5 - 16岁）测量了对比度干扰阈值。我们发现，在大多数剥夺性弱视儿童中，至少是间歇性地，以及所有屈光参差性或斜视性/屈光参差性混合弱视儿童中，双眼间抑制可以通过对比度平衡来克服。然而，因早期单侧或双侧白内障导致剥夺性弱视的儿童，对较强眼只能耐受非常低的对比度水平，这表明存在强烈的抑制。我们的结果表明，对于一部分剥夺性弱视儿童，可以尝试依赖对比度平衡双眼呈现的治疗方案。
