Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, Innsbruck, Austria.
Semin Cancer Biol. 2017 Jun;44:170-181. doi: 10.1016/j.semcancer.2017.02.006. Epub 2017 Feb 13.
Exosomes are small membrane vesicles with a size ranging from 40 to 100nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes influence every step of this cascade and can be targeted by oncological treatment. This review highlights the role of exosomes in the various steps of the metastatic cascade and how exosome dependent pathways can be targeted as therapeutic approach or used for liquid biopsies.
外泌体是一种大小在 40 至 100nm 之间的小型膜囊泡。它们可以作为细胞相互作用的功能介质，导致癌症转移。转移是癌细胞侵袭、在血管中存活、附着和定植宿主器官的一个复杂的多步骤过程。外泌体影响这一级联反应的每一步，可以作为肿瘤治疗的靶点。这篇综述强调了外泌体在转移级联的各个步骤中的作用，以及如何针对外泌体依赖的途径作为治疗方法或用于液体活检。
