Haroon Al Rasheed Mohamed Rizwan, Acosta Andres, Tarjan Gabor
Department of Pathology, University of Illinois at Chicago, 840 S. Wood Street, Suite 130 CSN, Chicago, IL, 60612, USA.
Department of Pathology, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL, USA.
Pathol Res Pract. 2017 Apr;213(4):416-421. doi: 10.1016/j.prp.2016.12.026. Epub 2017 Jan 5.
Spindle cell lesions of the thyroid are rare overall, and span a wide clinical spectrum that ranges from spindle cell metaplasia (SCM) to anaplastic carcinoma. Their differentiation is only seldom straightforward, and usually requires the integration of the clinical, histological and immunohistochemical data. Only a handful of publications have described cases of SCM in the thyroid and we add to that literature by reporting a unique case of encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with SCM. In addition, we review the literature on the relationship between SCM and different thyroid lesions, summarizing the morphological and immunohistochemical features that aid in its differentiation from more aggressive spindle cell proliferations.
甲状腺的梭形细胞病变总体上较为罕见，临床谱广泛，涵盖从梭形细胞化生（SCM）到未分化癌。它们的鉴别诊断很少是直接明了的，通常需要整合临床、组织学和免疫组化数据。仅有少数出版物描述过甲状腺SCM病例，我们通过报告一例具有SCM的包膜型乳头状甲状腺癌/具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤的独特病例，为该文献增添了内容。此外，我们回顾了关于SCM与不同甲状腺病变之间关系的文献，总结了有助于将其与更具侵袭性的梭形细胞增殖相鉴别的形态学和免疫组化特征。
