Shaikh Nader, Wald Ellen R
General Academic Pediatrics, Children's Hospital of Pittsburgh, 3414 Fifth Ave, Suite 301, Pittsburgh, PA, USA, 15213.
Cochrane Database Syst Rev. 2014 Oct 27;2014(10):CD007909. doi: 10.1002/14651858.CD007909.pub4.
The efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis has not been systematically evaluated.
To determine the efficacy of decongestants, antihistamines or nasal irrigation in improving symptoms of acute sinusitis in children.
We searched CENTRAL (2014, Issue 5), MEDLINE (1950 to June week 1, 2014) and EMBASE (1950 to June 2014).
We included randomized controlled trials (RCTs) and quasi-RCTs, which evaluated children younger than 18 years of age with acute sinusitis, defined as 10 to 30 days of rhinorrhea, congestion or daytime cough. We excluded trials of children with chronic sinusitis and allergic rhinitis.
Two review authors independently assessed each study for inclusion.
Of the 662 studies identified through the electronic searches and handsearching, none met all the inclusion criteria.
AUTHORS' CONCLUSIONS: There is no evidence to determine whether the use of antihistamines, decongestants or nasal irrigation is efficacious in children with acute sinusitis. Further research is needed to determine whether these interventions are beneficial in the treatment of children with acute sinusitis.
减充血剂、抗组胺药和鼻腔冲洗对临床诊断为急性鼻窦炎的儿童的疗效尚未得到系统评估。
确定减充血剂、抗组胺药或鼻腔冲洗对改善儿童急性鼻窦炎症状的疗效。
我们检索了Cochrane系统评价数据库（2014年第5期）、医学索引数据库（1950年至2014年6月第1周）和荷兰医学文摘数据库（1950年至2014年6月）。
我们纳入了随机对照试验（RCT）和半随机对照试验，这些试验评估了年龄小于18岁的急性鼻窦炎儿童，急性鼻窦炎定义为有10至30天的流涕、鼻塞或日间咳嗽。我们排除了慢性鼻窦炎和变应性鼻炎儿童的试验。
两位综述作者独立评估每项研究是否纳入。
通过电子检索和手工检索确定的662项研究中，没有一项符合所有纳入标准。
没有证据表明抗组胺药、减充血剂或鼻腔冲洗对急性鼻窦炎儿童是否有效。需要进一步研究以确定这些干预措施对治疗急性鼻窦炎儿童是否有益。
