不动杆菌分泌的奥秘。
The Secrets of Acinetobacter Secretion.
作者信息
Weber Brent S, Kinsella Rachel L, Harding Christian M, Feldman Mario F
机构信息
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA; Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.
出版信息
Trends Microbiol. 2017 Jul;25(7):532-545. doi: 10.1016/j.tim.2017.01.005. Epub 2017 Feb 16.
Abstract
Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs). In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.
摘要
由鲍曼不动杆菌这种细菌病原体引起的感染，日益引起医疗从业者的关注，因为广泛存在的抗生素耐药性持续限制着治疗选择。鲍曼不动杆菌致病所采用的生物学过程尚未完全明确，但最近的研究表明，分泌蛋白可能起主要作用。现已证明，包括II型分泌系统（T2SS）、VI型分泌系统（T6SS）、自转运蛋白和外膜囊泡（OMV）在内，多种机制有助于鲍曼不动杆菌及不动杆菌属其他致病菌种的蛋白质分泌。在本综述中，我们总结了不动杆菌属菌种分泌系统的现有知识，并强调了有助于这些新出现病原体致病性和持续性的独特方面。
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