Ruhdorfer A, Haniel F, Petersohn T, Dörrenberg J, Wirth W, Dannhauer T, Hunter D J, Eckstein F
Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.
Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.
Osteoarthritis Cartilage. 2017 Jul;25(7):1114-1121. doi: 10.1016/j.joca.2017.02.789. Epub 2017 Feb 12.
To examine cross-sectional and longitudinal between-group differences of infra-patellar fat pad (IPFP) size and magnetic resonance imaging (MRI) signal from fat-suppressed intermediate-weighted images with clinically relevant symptomatic and radiographic progression of knee osteoarthritis (OA), vs healthy references.
We studied 110 case knees (Kellgren-Lawrence Grade [KLG1-3]) with radiographic (≥0.7 mm loss in joint space width [JSW]) and symptomatic progression (≥+9/100 units on the Western Ontario and McMasters Universities Osteoarthritis Index [WOMAC] knee pain subscale) vs 118 control knees without progression from the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium cohort. We further studied 88 knees from the Osteoarthritis Initiative (OAI) healthy reference cohort without (risk factors) of knee OA. The IPFP was manually segmented using baseline and year-2 sagittal fat-suppressed intermediate-weighted spin-echo 3 T MRIs. Baseline measures and longitudinal change in IPFP volume and 3D MRI signal (mean, standard deviation [SD]) were compared between groups.
No statistically significant baseline differences in IPFP volume, 3D MRI signal mean or signal heterogeneity (SD) were observed between progressor and non-progressor OA knees. Yet, the IPFP 3D MRI signal SD, but not its volume, was statistically significantly greater in OA vs healthy knees. No statistically significant 2-year changes in IPFP volume were observed in either group, but the increase in 3D MRI signal heterogeneity (SD) was greater in progressor vs non-progressor knees, and was greater in OA vs healthy knees.
Whereas IPFP-related morphometric measures did not statistically significantly differ between groups, a stronger increase in 3D IPFP MRI signal and signal heterogeneity may be associated with radiographic/symptomatic progression of OA, when compared to non-progressive OA or healthy knees.
通过脂肪抑制中等加权图像，研究髌下脂肪垫（IPFP）大小及磁共振成像（MRI）信号在膝关节骨关节炎（OA）具有临床相关性的症状和影像学进展患者与健康对照之间的横断面及纵向组间差异。
我们研究了110例有影像学进展（关节间隙宽度[JSW]损失≥0.7 mm）和症状进展（西安大略和麦克马斯特大学骨关节炎指数[WOMAC]膝关节疼痛分量表≥ +9/100单位）的病例膝关节（凯尔格伦 - 劳伦斯分级[KLG 1 - 3]），并与美国国立卫生研究院基金会（FNIH）生物标志物联盟队列中118例无进展的对照膝关节进行比较。我们还研究了来自骨关节炎倡议（OAI）健康对照队列的88例无膝关节OA风险因素的膝关节。使用基线和第2年矢状面脂肪抑制中等加权自旋回波3T MRI手动分割IPFP。比较各组之间IPFP体积和3D MRI信号（平均值、标准差[SD]）的基线测量值和纵向变化。
在进展性和非进展性OA膝关节之间，未观察到IPFP体积、3D MRI信号平均值或信号异质性（SD）的基线差异有统计学意义。然而，OA膝关节的IPFP 3D MRI信号SD在统计学上显著高于健康膝关节，但其体积并非如此。两组中均未观察到IPFP体积有统计学意义的2年变化，但进展性膝关节与非进展性膝关节相比，3D MRI信号异质性（SD）的增加更大，且OA膝关节与健康膝关节相比也更大。
尽管与IPFP相关的形态学测量在组间无统计学显著差异，但与非进展性OA或健康膝关节相比，3D IPFP MRI信号及信号异质性的更强增加可能与OA的影像学/症状进展相关。
