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（波斯）对支气管哮喘的药理学评价。 （你提供的原文中“(Pers.)”表述不太明确完整意思，可能存在信息缺失，但按照要求逐字翻译如上）

Pharmacological evaluation of (Pers.) on bronchial asthma.

作者信息

Sahoo Himanshu Bhusan, Sagar Rakesh, Patro Ganesh, Panda Madhulita, Sahoo Saroj Kumar, Priyadarshini D

机构信息

Department of Pharmacology and Experimental Biology, Vedica College of Pharmacy, RKDF University, Bhopal, Madhya Pradesh, India.

Department of Pharmacology, College of Pharmaceutical Sciences, Mohuda, Berhampur, Odisha, India.

出版信息

J Pharm Bioallied Sci. 2016 Oct-Dec;8(4):341-345. doi: 10.4103/0975-7406.199343.

DOI:10.4103/0975-7406.199343
PMID:28216960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5314835/
Abstract

OBJECTIVE

The present study was to investigate the antiasthmatic potential from the flavonoid fraction of fruit (FFALF) to validate its traditional claim.

MATERIALS AND METHODS

The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0 and 7 day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups.

RESULTS

The treatments of FFALF were significantly ( < 0.001) decreased the histamine/acetylcholine-induced bronchospasm, mast cell degranulation, and histamine-induced tracheal contraction as compared to inducer group. In addition, FFALF showed dose-dependent antiasthmatic activity in all the animals.

CONCLUSION

Hence, this study suggested that the FFALF showed antiasthmatic activity probably by membrane stabilizing property as well as suppressing antibody production and inhibiting of antigen induced by histamine and acetylcholine.

摘要

目的

本研究旨在探究水果黄酮类成分（FFALF）的抗哮喘潜力，以验证其传统功效。

材料与方法

通过组胺或乙酰胆碱诱导豚鼠支气管痉挛模型、化合物48/80诱导白化大鼠肥大细胞脱颗粒以及组胺诱导豚鼠气管收缩来评估FFALF的抗哮喘活性。测量豚鼠支气管痉挛模型中100和200mg/kg剂量下第0天和第7天的惊厥前呼吸困难时间、大鼠中500、750和1000μg/ml剂量下肥大细胞颗粒化和脱颗粒的百分比以及豚鼠中500、750和1000μg/ml剂量下的气管收缩情况，并与各自的对照组进行比较。

结果

与诱导剂组相比，FFALF处理显著（<0.001）降低了组胺/乙酰胆碱诱导的支气管痉挛、肥大细胞脱颗粒以及组胺诱导的气管收缩。此外，FFALF在所有动物中均表现出剂量依赖性的抗哮喘活性。

结论

因此，本研究表明，FFALF可能通过膜稳定特性以及抑制抗体产生和组胺及乙酰胆碱诱导的抗原而表现出抗哮喘活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b2/5314835/83c8f0cf9ec4/JPBS-8-341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b2/5314835/2e9174d27cef/JPBS-8-341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b2/5314835/83c8f0cf9ec4/JPBS-8-341-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b2/5314835/2e9174d27cef/JPBS-8-341-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9b2/5314835/83c8f0cf9ec4/JPBS-8-341-g003.jpg

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