东方蜚蠊母酊剂的抗哮喘和抗过敏活性。
Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture.
作者信息
Chandrakant Nimgulkar Chetan, Dattatray Patil Savita, Dinesh Kumar B
机构信息
Food and Drug Toxicology Research Centre, National Institute of Nutrition, ICMR, Hyderabad, Andhra Pradesh, India.
出版信息
Homeopathy. 2011 Jul;100(3):138-43. doi: 10.1016/j.homp.2010.08.006.
OBJECTIVES
To study the anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture (B. orientalis MT), a homeopathic medicine, in experimental animal models.
METHODS
The anti-asthmatic activity of B. orientalis MT was studied in the bronchial hyperactivity models, acetylcholine and histamine induced bronchospasm, in guinea pigs. Anti-anaphylactic activity was tested by active and passive anaphylaxis models in rats, anti-eosinophilic activity was tested by milk-induced eosinophilia in mice.
RESULTS
Significant protection against acetylcholine and histamine aerosol-induced bronchospasm in B. orientalis MT treated guinea pigs was seen. In active and passive anaphylaxis albino rat models significant reduction in mesenteric mast cells degranulation, serum IgE level and eosinophil cell count was observed in the B. orientalis MT treated rat group when compared with the sensitized control rat group.
CONCLUSION
These results reveal broad activity of B. orientalis MT. It may have nonselective anti-asthmatic activity. The anti-anaphylactic activity of B. orientalis MT may be due to mast cell stabilization, suppression of IgE and eosinophil cell count.
目的
在实验动物模型中研究顺势疗法药物东方蜚蠊母酊剂（B. orientalis MT）的抗哮喘和抗过敏活性。
方法
在豚鼠的支气管高反应性模型、乙酰胆碱和组胺诱导的支气管痉挛模型中研究B. orientalis MT的抗哮喘活性。通过大鼠的主动和被动过敏反应模型测试抗过敏活性，通过小鼠牛奶诱导的嗜酸性粒细胞增多测试抗嗜酸性粒细胞活性。
结果
在接受B. orientalis MT治疗的豚鼠中，观察到对乙酰胆碱和组胺气雾剂诱导的支气管痉挛有显著保护作用。在主动和被动过敏反应白化大鼠模型中，与致敏对照大鼠组相比，接受B. orientalis MT治疗的大鼠组肠系膜肥大细胞脱颗粒、血清IgE水平和嗜酸性粒细胞计数显著降低。
结论
这些结果揭示了B. orientalis MT的广泛活性。它可能具有非选择性抗哮喘活性。B. orientalis MT的抗过敏活性可能归因于肥大细胞稳定、IgE抑制和嗜酸性粒细胞计数减少。
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