洛美20至39岁人群中乙肝病毒感染的高流行率
High Prevalence of Hepatitis B Virus Infection in the Age Range of 20-39 Years Old Individuals in Lome.
作者信息
Kolou Malewe, Katawa Gnatoulma, Salou Mounerou, Gozo-Akakpo Komlan Selom, Dossim Sika, Kwarteng Alexander, Prince-David Mireille
机构信息
Centre Hospitalier Universitaire (CHU) Campus, Lome, Togo; Faculte des Sciences de la Santé (FSS), Universite de Lome, Togo.
Ecole Superieure des Techniques Biologiques et Alimentaires (ESTBA), Universite de Lome, Togo.
出版信息
Open Virol J. 2017 Jan 12;11:1-7. doi: 10.2174/1874357901710011001. eCollection 2017.
BACKGROUND
Hepatitis B is a liver infection caused by the hepatitis B virus (HBV). It affects all women and men irrespective of age. Although sub-Saharan Africa is an area of high prevalence of this disease, data on the prevalence of acute and chronic HBV infections in this region remain to be widely documented.
OBJECTIVE
This study aimed to investigate the prevalence of HBV in relation to age in Centre Hospitalier Universitaire Campus (CHU-C), one of the two teaching hospitals of Lome, Togo.
METHOD
The present study is a cross-sectional study about the prevalence of hepatitis B surface antigen (HBsAg) carriage from 2009 to 2011. All study participants were screened for HBsAg at the Immunology laboratory of CHU Campus of Lome.
RESULTS
One thousand two hundred individuals were screened for HBsAg from 2009-2011. The overall prevalence of HBV infection was 19.08%. This prevalence was significantly higher in men (25.00%) than women (14.80%). The highest prevalence of HBV was observed in age range of 20-29 years and 30-39 years with respectively 26.33% and 21.67%. The lowest prevalence was 6.08%, found in people over 50 years. Concerning the clinical indication of the test, the prevalence during the clinical abnormalities related to liver (CARL) was the highest (26.21%), followed by the systematic screening (SS) with 20.25% while the pre-operative assessment (POA) showed the lowest prevalence with 5.56%.
CONCLUSION
The study shows the high prevalence of HBsAg carriage in young people. This could be used to enhance prevention and treatment of HBV infection in Togo.
背景
乙型肝炎是由乙型肝炎病毒（HBV）引起的肝脏感染。它影响所有年龄段的男性和女性。尽管撒哈拉以南非洲是该疾病的高流行地区，但该地区急性和慢性HBV感染的流行数据仍有待广泛记录。
目的
本研究旨在调查多哥洛美两所教学医院之一的中心医院大学校区（CHU-C）中HBV感染率与年龄的关系。
方法
本研究是一项关于2009年至2011年乙型肝炎表面抗原（HBsAg）携带率的横断面研究。所有研究参与者均在洛美CHU校区的免疫实验室进行了HBsAg筛查。
结果
2009年至2011年期间，对1200人进行了HBsAg筛查。HBV感染的总体患病率为19.08%。男性患病率（25.00%）显著高于女性（14.80%）。HBV感染率最高的年龄范围是20-29岁和30-39岁，分别为26.33%和21.67%。最低患病率为6.08%，出现在50岁以上人群中。关于检测的临床指征，与肝脏相关的临床异常（CARL）期间的患病率最高（26.21%），其次是系统筛查（SS），为20.25%，而术前评估（POA）的患病率最低，为5.56%。
结论
该研究表明年轻人中HBsAg携带率很高。这可用于加强多哥HBV感染的预防和治疗。
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