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加纳一家政府医院的乙肝病毒负担及趋势

The burden and trends of Hepatitis B virus at a government hospital in Ghana.

作者信息

Deku John G, Aninagyei Enoch, Kpene Godsway E, Bedzina Israel, Mensah Bismark, Agodey Isaac K, Edziah Florence S, Duneeh Richard V

机构信息

Department of Medical Laboratory Sciences, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.

Department of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.

出版信息

Ghana Med J. 2025 Jun;59(2):60-67. doi: 10.4314/gmj.v59i2.3.

DOI:10.4314/gmj.v59i2.3
PMID:40621407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12224210/
Abstract

OBJECTIVE

This study determined the burden and trend of Hepatitis B Virus (HBV) infection in individuals who visited Agona Government Hospital in Ghana.

DESIGN

A retrospective study.

SETTING

A single-centre study conducted at Agona Government Hospital.

PARTICIPANTS

Clients who visited Agona Government Hospital.

MAIN OUTCOME MEASURE

A hospital-based retrospective study was conducted. Data generated between January 2016 and December 2020 were extracted, cleaned, and validated using Microsoft Excel version 2019. Analysis was done using the Statistical Package for Social Sciences version 26.

RESULTS

A total of 2440 records from individuals who were tested for HBV were analysed. The records indicated varying numbers of tests each year, with 28.9% in 2016, 23.1% in 2017, 20.6% in 2018, 13.6% in 2019, and 13.7% in 2020. Most of the clients were aged 25-44 (46.3%). The majority of the clients were married (53.2%) and females (65.3%). The cumulative crude prevalence of HBV infection was 57.44 per 10,000. The prevalence of HBV varied across age categories and genders. A decline in prevalence was observed from 2016 to 2017, with a trough in 2018, followed by a rise through 2019 and peaking in 2020. The crude prevalence exhibited a peak in February and a trough in September, with inconsistent patterns throughout the year.

CONCLUSION

The high burden of HBV underscores its significance as a pressing public health issue. There is therefore an urgent need for public health interventions to curb the spread of the infection.

FUNDING

None declared.

摘要

目的

本研究确定了前往加纳阿戈纳政府医院就诊的个体中乙型肝炎病毒(HBV)感染的负担及趋势。

设计

一项回顾性研究。

地点

在阿戈纳政府医院开展的单中心研究。

参与者

前往阿戈纳政府医院就诊的患者。

主要观察指标

开展了一项基于医院的回顾性研究。提取了2016年1月至2020年12月期间产生的数据,使用Microsoft Excel 2019进行清理和验证。使用社会科学统计软件包第26版进行分析。

结果

共分析了2440例接受HBV检测的个体记录。记录显示每年的检测数量各不相同,2016年为28.9%,2017年为23.1%,2018年为20.6%,2019年为13.6%,2020年为13.7%。大多数患者年龄在25 - 44岁之间(46.3%)。大多数患者已婚(53.2%)且为女性(65.3%)。HBV感染的累积粗患病率为每10000人中有57.44例。HBV患病率在不同年龄组和性别中有所不同。2016年至2017年患病率下降,2018年出现低谷,随后在2019年上升并在2020年达到峰值。粗患病率在2月达到峰值,9月出现低谷,全年模式不一致。

结论

HBV的高负担凸显了其作为紧迫公共卫生问题的重要性。因此,迫切需要采取公共卫生干预措施来遏制感染的传播。

资金来源

未申报。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/1f1afd406eba/GMJ5902-0060Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/5caf6d08ae0e/GMJ5902-0060Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/d61a7debd18a/GMJ5902-0060Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/62904f3af0a4/GMJ5902-0060Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/1f1afd406eba/GMJ5902-0060Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/5caf6d08ae0e/GMJ5902-0060Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/d61a7debd18a/GMJ5902-0060Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/62904f3af0a4/GMJ5902-0060Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c7c/12224210/1f1afd406eba/GMJ5902-0060Fig4.jpg

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本文引用的文献

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World Hepatitis day 2021 -screening and vaccination against Hepatitis B virus in Accra, Ghana.2021 年世界肝炎日——在加纳阿克拉进行乙型肝炎病毒筛查和疫苗接种。
BMC Public Health. 2023 Jun 16;23(1):1164. doi: 10.1186/s12889-023-16108-6.
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Public relations strategies employed by the Ghana Health Service to address COVID-19 vaccine hesitancy: a qualitative inquiry.加纳卫生服务局为应对新冠疫苗犹豫情绪所采用的公共关系策略:一项定性调查
Trop Med Health. 2023 May 12;51(1):26. doi: 10.1186/s41182-023-00519-7.
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Risk factors associated with Hepatitis B virus infection among pregnant women attending public hospitals in Addis Ababa, Ethiopia.
埃塞俄比亚亚的斯亚贝巴公立医院孕妇乙型肝炎病毒感染相关的危险因素。
PLoS One. 2023 Apr 26;18(4):e0284646. doi: 10.1371/journal.pone.0284646. eCollection 2023.
4
Sociodemographic characteristics, complications requiring hospital admission and causes of in-hospital death in patients with liver cirrhosis admitted at a district hospital in Ghana.加纳地区医院收治的肝硬化患者的社会人口学特征、需要住院治疗的并发症以及住院死亡原因。
PLoS One. 2021 Jun 24;16(6):e0253759. doi: 10.1371/journal.pone.0253759. eCollection 2021.
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Hepatitis B Virus: From Diagnosis to Treatment.乙型肝炎病毒:从诊断到治疗。
Pol J Microbiol. 2020 Dec;69(4):391-399. doi: 10.33073/pjm-2020-044. Epub 2020 Dec 27.
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Oesophageal varices in patients with liver cirrhosis attending a major tertiary hospital in Ghana.加纳一家大型三级医院肝硬化患者的食管静脉曲张情况。
Pan Afr Med J. 2018 Dec 13;31:230. doi: 10.11604/pamj.2018.31.230.16657. eCollection 2018.
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Hepatitis B vaccination coverage among adults aged ≥ 18 years traveling to a country of high or intermediate endemicity, United States, 2015.2015 年,前往高或中度流行地区的≥18 岁成年人的乙型肝炎疫苗接种率,美国。
Vaccine. 2018 Apr 25;36(18):2471-2479. doi: 10.1016/j.vaccine.2018.03.030. Epub 2018 Mar 28.
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Sero-prevalence of hepatitis B infection among blood donors in a secondary care hospital, Ghana (2014): a retrospective analysis.加纳一家二级保健医院献血者中乙肝感染的血清流行率(2014年):一项回顾性分析
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Hepatitis B virus and its sexually transmitted infection - an update.乙型肝炎病毒及其性传播感染——最新进展
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