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Crystal structure of (1,3a,7a)-1-{()-1-[(2,5)-5-(3-hy-droxy-pentan-3-yl)tetra-hydro-furan-2-yl]eth-yl}-7a-methyl-2,3,3a,4,5,6,7,7a-octa-hydro-1-inden-4-one.

作者信息

Martínez Andrea, Santalla Hugo, Garrido Fátima, Barry Aliou Hamady, Gaye Mohamed, Fall Diop Yagamare

机构信息

Dipartamento Química Orgínica, Facultade de Química, Universidade de Vigo, E-36310, Vigo, Spain.

Département de Chimie, Faculté des Sciences, Université de Nouakchott, Nouakchott, Mauritania.

出版信息

Acta Crystallogr E Crystallogr Commun. 2017 Jan 6;73(Pt 2):115-117. doi: 10.1107/S2056989016020648. eCollection 2017 Feb 1.

DOI:10.1107/S2056989016020648
PMID:28217323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5290546/
Abstract

The title compound, CHO, contains an oxolane ring, and six defined stereocentres and may serve as a useful synthon for the synthesis of calcitriol analogues. The configurations of the chiral C atoms of the side chain were unambiguously established in the refinement. In the crystal, C-H⋯O and extremely weak O-H⋯O hydrogen bonds arising from the sterically hindered alcohol group link the mol-ecules into a three-dimensional network.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7e/5290546/9bcb58d59de2/e-73-00115-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7e/5290546/c46b9fa5164c/e-73-00115-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7e/5290546/9bcb58d59de2/e-73-00115-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7e/5290546/c46b9fa5164c/e-73-00115-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc7e/5290546/9bcb58d59de2/e-73-00115-fig2.jpg

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本文引用的文献

1
The Cambridge Structural Database.剑桥结构数据库。
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Apr;72(Pt 2):171-9. doi: 10.1107/S2052520616003954. Epub 2016 Apr 1.
2
Synthesis and crystallographic study of 1,25-dihydroxyergocalciferol analogs.1,25-二羟胆钙化醇类似物的合成及晶体学研究。
Steroids. 2013 Oct;78(10):1003-14. doi: 10.1016/j.steroids.2013.06.001. Epub 2013 Jun 28.
3
Use of intensity quotients and differences in absolute structure refinement.强度商数的使用及绝对结构精修中的差异
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2013 Jun;69(Pt 3):249-59. doi: 10.1107/S2052519213010014. Epub 2013 May 17.
4
(7aR)-1-[(2R,5S,E)-6-Hy-droxy-5,6-dimethyl-hept-3-en-2-yl]-7a-methyl-hexa-hydro-1H-inden-4(2H)-one.(7aR)-1-[(2R,5S,E)-6-羟基-5,6-二甲基-庚-3-烯-2-基]-7a-甲基-六氢-1H-茚-4(2H)-酮
Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o218. doi: 10.1107/S1600536812051343. Epub 2013 Jan 12.
5
Synthesis and biological evaluation of a new vitamin D2 analogue.新型维生素 D2 类似物的合成与生物评价。
Bioorg Med Chem Lett. 2012 Oct 1;22(19):6276-9. doi: 10.1016/j.bmcl.2012.07.095. Epub 2012 Aug 7.
6
Calcitriol derivatives with two different side chains at C-20. 24-hydroxy derivatives as metabolic products and molecular probes for VDR exploration.在C-20位具有两种不同侧链的骨化三醇衍生物。24-羟基衍生物作为代谢产物和用于维生素D受体探索的分子探针。
J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):35-8. doi: 10.1016/j.jsbmb.2004.03.047.