Kohli Aparna, Siddhu Anupa, Pandey Ravindra M, Reddy K Srinath
Public Health Foundation of India, Delhi-NCR, New Delhi, India; Department of Food and Nutrition, Lady Irwin College, University of Delhi, New Delhi, India.
Department of Food and Nutrition, Lady Irwin College, University of Delhi, New Delhi, India.
Indian J Endocrinol Metab. 2017 Jan-Feb;21(1):113-118. doi: 10.4103/2230-8210.196020.
Cardiovascular disease (CVD) is the largest cause of mortality in Indians. Insulin resistance and related dyslipidemia of increased triglyceride (TG), small dense low-density lipoprotein (sd-LDL) particles, and decreased high-density lipoprotein-cholesterol (HDL-C) are associated with increased risk of CVD. TG/HDL-C ratio could be a potential surrogate marker for this South Asian phenotype. Data are scarce on the relevance of TG/HDL-C ratio as a useful lipid marker among Indians.
To study the prevalence of TG/HDL-C ratio among healthy, young, and middle-aged Indian men (25-44 years) and its relationship with other lipid and nonlipid factors.
In this cross-sectional analysis, fasting blood samples from 236 healthy participants recruited from an urban community setting were tested for TG/HDL-C ratio, HDL-C, TG, total cholesterol (TC), non-HDL-C, TC/HDL-C, high-sensitivity C-reactive protein, body mass index (BMI), and body fat.
Mean (standard deviation) age of participants was 34.7 (7.7) years; median (interquartile range) TG/HDL-C ratio was 4 (2.85-5.2). More than half (51.3%) the participants ( = 121) recorded abnormal TG/HDL-C ratio (≥4.0). Across tertiles of TG/HDL-C ratio, there was a significant trend of higher conventional lipid parameters such as non-HDL-C*, TC/HDL-C ratio*, TG*, HDL-C*, TC**; and non-lipid parameters body-fat* and BMI*** (* < 0.001, ** = 0.015, *** = 0.002). LDL-C showed moderate and nonsignificant ( = 0.646) increase across tertiles.
In a sample of apparently healthy, young, and middle-aged Indian men abnormal TG/HDL-C ratio levels were observed among more than half the participants. The TG/HDL-C ratio was closely associated with other lipid parameters and measures of adiposity, such as BMI and body fat, apart from its previously documented unique association with sd-LDL particles. TG/HDL-C ratio should be evaluated in future for risk prediction of incident CVD among Indians.
心血管疾病（CVD）是印度人死亡的最大原因。胰岛素抵抗以及相关的血脂异常，如甘油三酯（TG）升高、小而密低密度脂蛋白（sd-LDL）颗粒增加和高密度脂蛋白胆固醇（HDL-C）降低，与心血管疾病风险增加相关。TG/HDL-C比值可能是这种南亚表型的潜在替代标志物。关于TG/HDL-C比值作为印度人有用的血脂标志物的相关性的数据很少。
研究健康、年轻和中年印度男性（25 - 44岁）中TG/HDL-C比值的患病率及其与其他血脂和非血脂因素的关系。
在这项横断面分析中，对从城市社区招募的236名健康参与者的空腹血样进行了TG/HDL-C比值、HDL-C、TG、总胆固醇（TC）、非HDL-C、TC/HDL-C、高敏C反应蛋白、体重指数（BMI）和体脂检测。
参与者的平均（标准差）年龄为34.7（7.7）岁；TG/HDL-C比值的中位数（四分位间距）为4（2.85 - 5.2）。超过一半（51.3%）的参与者（n = 121）记录到TG/HDL-C比值异常（≥4.0）。在TG/HDL-C比值的三分位数中，传统血脂参数如非HDL-C*、TC/HDL-C比值*、TG*、HDL-C*、TC**；以及非血脂参数体脂和BMI**呈现显著升高趋势（*P < 0.001，**P = 0.015，***P = 0.002）。LDL-C在三分位数中呈现中度且无显著意义（P = 0.646）的升高。
在一个看似健康的年轻和中年印度男性样本中，超过一半的参与者观察到TG/HDL-C比值水平异常。TG/HDL-C比值除了与sd-LDL颗粒有先前记录的独特关联外，还与其他血脂参数以及肥胖指标如BMI和体脂密切相关。未来应评估TG/HDL-C比值用于预测印度人心血管疾病发病风险。
