关于……肝毒性的影响因素
Influence Factors on the Hepatotoxicity of .
作者信息
Wei Yun, Liu Meixia, Liu Jiangang, Li Hao
机构信息
Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
出版信息
Evid Based Complement Alternat Med. 2019 Sep 25;2019:5482896. doi: 10.1155/2019/5482896. eCollection 2019.
Abstract
BACKGROUND
Chinese herbal medicine (CHM) with reported hepatotoxicity is identified, in which (HSW) attracts most attention. According to the Traditional Chinese Medicine (TCM) theory, processing is believed to be able to reduce the toxicity of HSW, but in publications, both processed and unprocessed HSW are reported to cause liver injury.
METHODS
This article reviews the case reports and experimental researches involving liver damage associated with HSW from the following aspects: clinical features, hepatic toxicity components, hepatotoxicity mechanism, and so on.
RESULTS
HSW has hepatotoxicity in different degrees and even leads to death, and the reason is multioriginal.
CONCLUSIONS
People should be educated to have a broad understanding on ensuring drug use safety and lower drug-induced risks when taking HSW preparations.
摘要
背景
已鉴定出具有肝毒性报道的中药，其中何首乌（HSW）备受关注。根据中医理论，炮制被认为能够降低何首乌的毒性，但在出版物中，炮制和未炮制的何首乌均有导致肝损伤的报道。
方法
本文从临床特征、肝毒性成分、肝毒性机制等方面综述了涉及何首乌相关肝损伤的病例报告和实验研究。
结果
何首乌具有不同程度的肝毒性，甚至可导致死亡，原因是多方面的。
结论
应教育人们在服用何首乌制剂时，对确保用药安全和降低药物诱导风险有广泛的认识。
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