Yang H, Du Bois D R, Ziller J W, Nowick J S
Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
Chem Commun (Camb). 2017 Feb 28;53(18):2772-2775. doi: 10.1039/c7cc00783c.
The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.
截短的替考拉宁类似物的X射线晶体结构揭示了氢键和疏水相互作用以及一个结合氯离子阴离子的空腔。针对革兰氏阳性菌的最低抑菌浓度（MIC）测定将观察到的结构与抗生素活性相关联。
