Tedeschi Sara K, Frits Michelle, Cui Jing, Zhang Zhi Zack, Mahmoud Taysir, Iannaccone Christine, Lin Tzu-Chieh, Yoshida Kazuki, Weinblatt Michael E, Shadick Nancy A, Solomon Daniel H
Brigham and Women's Hospital, Boston, Massachusetts.
Arthritis Care Res (Hoboken). 2017 Dec;69(12):1920-1925. doi: 10.1002/acr.23225.
Patients with rheumatoid arthritis (RA) often ask whether specific foods, popularized as inflammatory or antiinflammatory, can improve or worsen their RA. Patients with RA took a survey on diet and RA symptoms, and the survey data were collected and analyzed.
A dietary survey was mailed to 300 subjects in a single-center RA registry at a large academic center. Subjects were asked about their consumption of 20 foods and whether these foods make their RA symptoms better, worse, or unchanged. Semiannual registry data include demographics, medications, comorbidities, and disease activity scores. Fisher's exact test and Wilcoxon's rank sum tests evaluated associations between subject characteristics from the most recent registry assessment and changes in RA symptoms from specific foods.
Of the 217 subjects (72% response rate), 83% were female; the median RA duration was 17 years (interquartile range 9-27 years), and 58% were taking a biologic disease-modifying antirheumatic drug. Twenty-four percent of subjects reported that foods affect their RA symptoms, with 15% reporting improvement and 19% reporting worsening. Blueberries and spinach were the foods most often reported to improve RA symptoms, while soda with sugar and desserts were those most often reported to worsen RA symptoms. Younger age and noting that sleep, warm room temperature, and vitamin/mineral supplements improve RA were each associated with reporting that foods affect RA symptoms. Medication use, sex, body mass index, smoking, disease duration, disease activity scores, and self-reported RA flares were not associated with reporting that foods affect RA.
Nearly one-quarter of RA subjects with longstanding disease reported that diet had an effect on their RA symptoms.
类风湿关节炎（RA）患者常常询问，那些被宣传为具有促炎或抗炎作用的特定食物，是否会改善或加重他们的类风湿关节炎病情。患有类风湿关节炎的患者进行了一项关于饮食与类风湿关节炎症状的调查，并对调查数据进行了收集和分析。
向一家大型学术中心单中心类风湿关节炎登记处的300名受试者邮寄了一份饮食调查问卷。询问受试者20种食物的食用情况，以及这些食物是否使他们的类风湿关节炎症状改善、恶化或未改变。半年一次的登记数据包括人口统计学信息、用药情况、合并症以及疾病活动评分。采用Fisher精确检验和Wilcoxon秩和检验来评估来自最近一次登记评估的受试者特征与特定食物导致的类风湿关节炎症状变化之间的关联。
在217名受试者（应答率72%）中，83%为女性；类风湿关节炎的中位病程为17年（四分位间距9 - 27年），58%的受试者正在使用生物性改善病情抗风湿药。24%的受试者报告食物会影响他们的类风湿关节炎症状，其中15%报告症状改善，19%报告症状恶化。蓝莓和菠菜是最常被报告能改善类风湿关节炎症状的食物，而含糖汽水和甜点是最常被报告会加重类风湿关节炎症状的食物。年龄较小以及注意到睡眠、温暖的室温以及维生素/矿物质补充剂能改善类风湿关节炎，均与报告食物会影响类风湿关节炎症状相关。用药情况、性别、体重指数、吸烟、病程、疾病活动评分以及自我报告的类风湿关节炎病情加重，均与报告食物会影响类风湿关节炎无关。
近四分之一患有长期类风湿关节炎的受试者报告饮食对他们的类风湿关节炎症状有影响。
