Kaçar Mutlutürk Ülger, Çiçek Betül, Cengiz Gizem
Department of Nutrition and Dietetics, Institute of Health Sciences, Erciyes University, Kayseri 38039, Türkiye.
Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Kayseri 38260, Türkiye.
Life (Basel). 2025 Mar 14;15(3):463. doi: 10.3390/life15030463.
The gut microbiota composition of rheumatoid arthritis (RA) patients differs from healthy people, and diet is among the powerful environmental determinants that can alter the microbiota. The purpose of this clinical research was to identify the effect of the Ideal Food Pyramid on gut microbiota in RA, as well as its impact on disease activity, biochemical findings and anthropometric measurements.
Thirty patients diagnosed with RA that met the inclusion criteria were randomized into diet and control groups and followed for 12 weeks. The gut microbiota composition was indicated by 16SrRNA gene sequencing.
At the end of this study, Simpson, Shannon and Chao-1 indices were higher in the diet group (16) than in the control group (14), although not significantly ( > 0.05). In the diet group, at phylum levels, the abundance of decreased while the abundance of increased. At species level, , , , decreased, while , , , , , , , and species increased in the diet group.
The Ideal Food Pyramid has been determined to have many clinical benefits for RA patients, especially for the gut microbiota.
类风湿关节炎（RA）患者的肠道微生物群组成与健康人不同，饮食是能够改变微生物群的重要环境决定因素之一。这项临床研究的目的是确定理想食物金字塔对RA患者肠道微生物群的影响，以及其对疾病活动、生化指标和人体测量的影响。
30名符合纳入标准的RA诊断患者被随机分为饮食组和对照组，并随访12周。通过16SrRNA基因测序来显示肠道微生物群组成。
在本研究结束时，饮食组（16）的辛普森指数、香农指数和Chao-1指数高于对照组（14），但差异不显著（>0.05）。在饮食组中，在门水平上，[具体菌门名称1]的丰度下降，而[具体菌门名称2]的丰度增加。在物种水平上，[具体物种名称1]、[具体物种名称2]、[具体物种名称3]、[具体物种名称4]减少，而饮食组中[具体物种名称5]、[具体物种名称6]、[具体物种名称7]、[具体物种名称8]、[具体物种名称9]、[具体物种名称10]、[具体物种名称11]、[具体物种名称12]物种增加。
已确定理想食物金字塔对RA患者有许多临床益处，尤其是对肠道微生物群。
