Anitua Eduardo, Pino Ander, Martinez Nahikari, Orive Gorka, Berridi Daniel
*Department of Dermatology, BTI Biotechnology Institute, Vitoria, Spain; †Eduardo Anitua Foundation, Vitoria, Álava, Spain; ‡Clínica Dermatológica, Vitoria, Spain.
Dermatol Surg. 2017 May;43(5):658-670. doi: 10.1097/DSS.0000000000001049.
Autologous growth factors have proved to promote tissue regeneration in various medical fields. Recent findings suggest that platelet rich plasma may also play an important role in hair follicle restoration.
The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA).
Five PRGF injections were administered over 19 patients with AGA. Phototrichograms regarding follicle density/diameter and terminal/vellus hair ratio were performed at baseline and after 1 year follow-up period. Consenting participants underwent histologic scalp examination. At the end of the study, overall patient satisfaction and clinical improvement were determined.
After PRGF therapy, mean hair density/diameter increased and terminal/vellus hair ratio was also improved. Patients presented epidermal thickness, perifollicular neoangiogenesis, cell proliferation, and terminal/miniaturized hair ratio improvement. Plasma rich in growth factors seemed to reduce the perivascular inflammatory infiltrate, promote the remodeling of dermo-epidermal tissue, and increase bulge stem cell niches. Patients declared an overall positive satisfaction, and a high clinical improvement score was achieved when comparing premacrophotographs and postmacrophotographs.
Although randomized clinical trials are needed, this study provides preliminary data supporting the positive therapeutic effect of autologous growth factors on hair follicle regeneration.
自体生长因子已被证明可促进各个医学领域的组织再生。最近的研究结果表明，富血小板血浆在毛囊修复中也可能发挥重要作用。
本研究的目的是评估富含生长因子的血浆（PRGFs）治疗雄激素性脱发（AGA）的安全性和临床疗效。
对19例AGA患者进行了5次PRGF注射。在基线和1年随访期后进行了关于毛囊密度/直径和终毛/毳毛比例的毛发照相。同意参与的受试者接受了头皮组织学检查。在研究结束时，确定了患者的总体满意度和临床改善情况。
PRGF治疗后，平均头发密度/直径增加，终毛/毳毛比例也得到改善。患者的表皮厚度、毛囊周围新生血管形成、细胞增殖以及终毛/微小化毛发比例均有改善。富含生长因子的血浆似乎减少了血管周围的炎性浸润，促进了真皮-表皮组织的重塑，并增加了隆突干细胞龛。患者总体满意度良好，比较治疗前和治疗后的宏观照片时，临床改善评分较高。
尽管需要进行随机临床试验，但本研究提供了初步数据，支持自体生长因子对毛囊再生具有积极治疗作用。
